on February 2, 2006
Arteriosclerosis, Thrombosis, and Vascular Biology. 2006
Published online before print February 2, 2006, doi: 10.1161/01.ATV.0000206123.94140.f3
Published online before print February 2, 2006, doi: 10.1161/01.ATV.0000206123.94140.f3
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Submitted on October 11, 2005
Accepted on January 18, 2006
The Role of Circulating Vascular Progenitors in Angiogenesis, Vascular Healing, and Pulmonary Hypertension. Lessons From Animal Models
Masataka Sata *
From the Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Japan; Department of Advanced Clinical Science and Therapeutics, University of Tokyo Graduate School of Medicine, Japan; and PRESTO, JST, Kawaguchi, Japan.
* To whom correspondence should be addressed. E-mail: msata-tky{at}umin.ac.jp.
Abstract--Accumulating evidence suggests that circulating progenitors contribute to vascular healing and remodeling under physiological and pathological conditions. Although there is growing enthusiasm for therapeutic and diagnostic application of bone marrow-derived progenitors, there are concerns that transplanted precursors or bone marrow cells may participate in the pathogenesis of unfavorable diseases such as cancer, retinopathy, and atherosclerosis. This review summarizes recent findings obtained from animal models to examine the roles of circulating vascular progenitor cells in angiogenesis, pulmonary hypertension, and vascular healing.
Key words: stem cell • angiogenesis • cancer • regeneration • progenitor
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