on December 22, 2005
Published online before print December 22, 2005, doi: 10.1161/01.ATV.0000201069.47550.8b
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on October 26, 2005
Accepted on December 8, 2005
Applications of Nanotechnology to Atherosclerosis, Thrombosis, and Vascular Biology
Samuel A. Wickline *;
From Washington University, Departments of Medicine (S.A.W., P.W., G.L.) and Biomedical Engineering (S.A.W., A.M.N., G.L.), St Louis, Mo, and Philips Medical Systems (S.C.), Best, the Netherlands.
* To whom correspondence should be addressed. E-mail: wicklines{at}aol.com.
Abstract--The role of nanotechnology in cardiovascular diagnosis is expanding rapidly. The goal of this brief review is to illustrate selected examples of nanosystems that have been applied to the arenas of atherosclerosis, thrombosis, and vascular biology. The technologies for producing targeted nanosystems are multifarious and reflect end uses in many cases. The results to date indicate rapid growth of interest and capability in the field. The future of cardiovascular diagnosis already is being impacted by nanosystems that can both diagnose pathology and treat it with targeted delivery systems.
Key words: nanotechnology • contrast agents • imaging • drug therapy
This article has been cited by other articles:
 |
|
 |
|
  P. Libby, P. M. Ridker, G. K. Hansson, and for the Leducq Transatlantic Network on Atherothro Inflammation in Atherosclerosis: From Pathophysiology to Practice J. Am. Coll. Cardiol., December 1, 2009; 54(23): 2129 - 2138. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R.-J. J.H.M. Miserus, M. V. Herias, L. Prinzen, M. B.I. Lobbes, R.-J. Van Suylen, A. Dirksen, T. M. Hackeng, J. W.M. Heemskerk, J. M.A. van Engelshoven, M. J.A.P. Daemen, et al. Molecular MRI of Early Thrombus Formation Using a Bimodal {alpha}2-Antiplasmin-Based Contrast Agent J. Am. Coll. Cardiol. Img., August 1, 2009; 2(8): 987 - 996. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. P. Choudhury and E. A. Fisher Molecular Imaging in Atherosclerosis, Thrombosis, and Vascular Inflammation Arterioscler Thromb Vasc Biol, July 1, 2009; 29(7): 983 - 991. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Nakano, K. Egashira, S. Masuda, K. Funakoshi, G. Zhao, S. Kimura, T. Matoba, K. Sueishi, Y. Endo, Y. Kawashima, et al. Formulation of Nanoparticle-Eluting Stents by a Cationic Electrodeposition Coating Technology: Efficient Nano-Drug Delivery via Bioabsorbable Polymeric Nanoparticle-Eluting Stents in Porcine Coronary Arteries J. Am. Coll. Cardiol. Intv., April 1, 2009; 2(4): 277 - 283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. J. Sarembock From Systemic Shotgun to Site-Specific Nanoparticle-Targeted Delivery: A New Paradigm for Drug Delivery Arterioscler Thromb Vasc Biol, November 1, 2008; 28(11): 1879 - 1881. [Full Text] [PDF]
|
|
|
|
|
|
M. A. McAteer, J. E. Schneider, Z. A. Ali, N. Warrick, C. A. Bursill, C. von zur Muhlen, D. R. Greaves, S. Neubauer, K. M. Channon, and R. P. Choudhury Magnetic Resonance Imaging of Endothelial Adhesion Molecules in Mouse Atherosclerosis Using Dual-Targeted Microparticles of Iron Oxide Arterioscler Thromb Vasc Biol, January 1, 2008; 28(1): 77 - 83. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. A. Jaffer, P. Libby, and R. Weissleder Molecular Imaging of Cardiovascular Disease Circulation, August 28, 2007; 116(9): 1052 - 1061. [Full Text] [PDF]
|
|
|
|
 |
|
 R. F. Mattrey Are Cerebral Emboli Real When Perfluorocarbon Emulsion (AF0144) is Used in Cardiac Surgery? Ann. Thorac. Surg., May 1, 2007; 83(5): 1922 - 1923. [Full Text] [PDF]
|
|
|
|
 |
|
 X. Yang Nano- and Microparticle-based Imaging of Cardiovascular Interventions: Overview Radiology, May 1, 2007; 243(2): 340 - 347. [Abstract] [Full Text] [PDF]
|
|