on December 8, 2005
Published online before print December 8, 2005, doi: 10.1161/01.ATV.0000199679.40501.ac
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Submitted on January 24, 2005
Accepted on November 29, 2005
Conjugated Linoleic Acid Impairs Endothelial Function
Justin S.W. Taylor *;
From Wales Heart Research Institute, Cardiff, UK; University of Glamorgan, Pontypridd, UK; Royal Glamorgan Hospital, Llantrisant, UK; Wales Heart Research Institute, Cardiff, UK; Dept Cardiovascular Medicine, The University of Birmingham, Birmingham, UK.
* To whom correspondence should be addressed. E-mail: jswt{at}totalise.co.uk.
Objectives--To determine the effect of dietary supplementation with conjugated linoleic acid (CLA) on body mass index (BMI), body fat distribution, endothelial function, and markers of cardiovascular risk.
Methods and Results--Forty healthy volunteers with BMI >27 kg/m2 were randomized to receive a CLA isomeric mixture or olive oil in a 12-week double-blind study. Subcutaneous body fat and abdominal/hepatic fat content were assessed using skin-fold thicknesses and computed tomography scanning, respectively. Endothelial function was assessed by brachial artery flow-mediated dilatation (FMD). Plasma isoprostanes were measured as an index of oxidative stress. CLA supplementation did not result in a significant change in BMI index or total body fat. There was a significant decrease in limb (-7.8 mm, P<0.001), but not torso skin-fold thicknesses or abdominal or liver fat content. Brachial artery FMD declined (-1.3%, P=0.013), and plasma F2-isoprostanes increased (+91pg/mL, P=0.042).
Conclusions--A CLA isomeric mixture had at most modest effects on adiposity and worsened endothelial function. On the basis of these results, the use of the isomeric mixture of CLA as an aid to weight loss cannot be recommended.
Key words: body composition • conjugated linoleic acid • endothelial function • obesity • oxidative stress
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