Donate Help Contact The AHA Sign In Home
American Heart Association
Arteriosclerosis, Thrombosis, and Vascular Biology
Search: search_blue_button Advanced Search
Published Online
on December 8, 2005

Arteriosclerosis, Thrombosis, and Vascular Biology. 2005
Published online before print December 8, 2005, doi: 10.1161/01.ATV.0000199268.27395.4f
A more recent version of this article appeared on February 1, 2006
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
26/2/250    most recent
01.ATV.0000199268.27395.4fv1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Perlstein, T. S.
Right arrow Articles by Lee, R. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Perlstein, T. S.
Right arrow Articles by Lee, R. T.

Submitted on September 20, 2005
Accepted on November 28, 2005

Smoking, Metallproteinases, and Vascular Disease

Todd S. Perlstein and Richard T. Lee *

From the Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, Mass.

* To whom correspondence should be addressed. E-mail: rlee{at}rics.bwh.harvard.edu.

Abstract--Smoking causes up to 11% of total global cardiovascular deaths. Smoking has numerous effects that may promote atherosclerosis through vascular inflammation and oxidative stress, but the pathogenesis of smoking-related cardiovascular disease remains incompletely understood. The matrix metalloproteinases, a family of endopeptidases that can degrade extracellular matrix components in both physiological and pathophysiological states, play an important role in smoking-associated chronic obstructive pulmonary disease, the second leading cause of smoking attributable mortality. Emerging evidence indicates that the matrix metalloproteinases may also contribute to smoking-related vascular disease. Here we discuss the potential relationship between smoking, matrix metalloproteinases, and acceleration of vascular disease.




This article has been cited by other articles:


Home page
 ANGIOLOGYHome page
S. Agarwal
The Association of Active and Passive Smoking With Peripheral Arterial Disease: Results From NHANES 1999-2004
Angiology, June 1, 2009; 60(3): 335 - 345.
[Abstract] [PDF]

Home page
 Am J EpidemiolHome page
A. Kifley, G. Liew, J. J. Wang, S. Kaushik, W. Smith, T. Y. Wong, and P. Mitchell
Long-term Effects of Smoking on Retinal Microvascular Caliber
Am. J. Epidemiol., December 1, 2007; 166(11): 1288 - 1297.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Heart FailHome page
E. Castardeli, D. R. Duarte, M. F. Minicucci, P. S. Azevedo, B. B. Matsubara, L. S. Matsubara, A. O. Campana, S. A.R. Paiva, and L. A.M. Zornoff
Tobacco smoke-induced left ventricular remodelling is not associated with metalloproteinase-2 or -9 activation
Eur J Heart Fail, November 1, 2007; 9(11): 1081 - 1085.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
D. Kelly, G. Cockerill, L. L. Ng, M. Thompson, S. Khan, N. J. Samani, and I. B. Squire
Plasma matrix metalloproteinase-9 and left ventricular remodelling after acute myocardial infarction in man: a prospective cohort study
Eur. Heart J., March 5, 2007; (2007) ehm003v1.
[Abstract] [Full Text] [PDF]


ATVB Home | Subscriptions | Archives | Feedback | Authors | Help | AHA Journals Home | Search
Copyright © 2005 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited.