on October 20, 2005
Published online before print October 20, 2005, doi: 10.1161/01.ATV.0000191663.12164.77
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Submitted on March 23, 2005
Accepted on October 12, 2005
Obesity, Peroxisome Proliferator-Activated Receptor, and Atherosclerosis in Type 2 Diabetes
Florian Blaschke *;
From the Division of Endocrinology, Diabetes, and Hypertension (F.B., Y.T., E.C., W.A.H.), David Geffen School of Medicine, University of California, Los Angeles, Calif; the Department of Medicine/Cardiology (F.B.), German Heart Institute, Berlin, Germany; and the Department of Medical and Scientific Affairs (R.E.L.), Takeda Pharmaceuticals North America, Inc, Lincolnshire, Ill.
* To whom correspondence should be addressed. E-mail: fblaschke{at}mednet.ucla.edu.
Abstract--Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. The 3 PPAR isotypes, PPAR-
, PPAR-
, and PPAR-
, play a key role in the regulation of lipid and glucose metabolism. Obesity and the interrelated disorders of the metabolic syndrome have become a major worldwide health problem. In this review, we summarize the critical role of PPARs in regulating inflammation, lipoprotein metabolism, and glucose homeostasis and their potential implications for the treatment of obesity, diabetes, and atherosclerosis.
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