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on October 13, 2005

Arteriosclerosis, Thrombosis, and Vascular Biology. 2005
Published online before print October 13, 2005, doi: 10.1161/01.ATV.0000190675.08857.3d
A more recent version of this article appeared on December 1, 2005
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*PROSTAGLANDIN F2ALPHA

Submitted on August 25, 2005
Accepted on October 3, 2005

Measures of Oxidized Low-Density Lipoprotein and Oxidative Stress Are Not Related and Not Elevated in Otherwise Healthy Men With the Metabolic Syndrome

Per Sjogren *; Samar Basu ; Magdalena Rosell ; Angela Silveira ; Ulf de Faire ; Bengt Vessby ; Anders Hamsten ; Mai-Lis Hellenius ; and Rachel M. Fisher

From the Department of Medicine, Atherosclerosis Research Unit (P.S., A.S., A.H., R.M.F.), Karolinska Institutet; the Department of Public Health and Caring Sciences (S.B., B.V.), University of Uppsala; and the Institute of Environmental Medicine (M.R., U.d.F.) and Center for Family and Community Medicine (M.-L.H.), Karolinska Institutet, Sweden.

* To whom correspondence should be addressed. E-mail: per.sjogren{at}medks.ki.se.

Objective--The metabolic syndrome predisposes to the development of cardiovascular diseases. Oxidative stress and elevated circulating oxidized low-density lipoprotein (LDL) concentrations are related to cardiovascular disease and proposed to be features of the metabolic syndrome. F2-isoprostanes are lipid peroxidation products and considered the most reliable biomarkers of oxidative stress.

Methods and Results--Plasma oxidized LDL (oxLDL) and urinary 8-iso-prostaglandin F2{alpha} (PGF2{alpha}; the major F2-isoprostane) were analyzed in a cross-sectional study of 289 healthy men (62 to 64 years of age). Individuals completed a 7-day dietary record, and fasting plasma insulin, lipid, and lipoprotein concentrations, LDL particle size, and inflammatory markers were determined. National Cholesterol Education Program/Adult Treatment Panel III (NCEP/ATPIII) criteria were used to define the metabolic syndrome and individuals were grouped according to the number of risk factors for the metabolic syndrome (0, [n=88; 30%]; ≥1, [n=179; 62%], metabolic syndrome [n=22; 8%]). Group comparisons revealed no differences for oxLDL, 8-iso-PGF2{alpha}, or reported intake of macronutrients, whereas C-reactive protein and interleukin-6 were increased in the metabolic syndrome. LDL cholesterol strongly determined oxLDL in univariate and multivariate analysis, but no relationship to 8-iso-PGF2{alpha} was found. In turn, 8-iso-PGF2{alpha} was related to reported intake of fat, fatty acids, and dietary antioxidants.

Conclusions--There were no increases in plasma oxLDL or measures of oxidative stress (urinary 8-iso-PGF2{alpha}) in these otherwise healthy 63-year-old men with the metabolic syndrome. Furthermore, no relationship between oxLDL and 8-iso-PGF2{alpha} was found, but our results suggest a role for dietary factors in oxidative stress.
Key words: metabolic syndrome • oxLDL • isoprostanes • oxidative stress • diet




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