on September 29, 2005
Published online before print September 29, 2005, doi: 10.1161/01.ATV.0000188508.40052.35
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on June 7, 2005
Accepted on September 6, 2005
Production of Chemokines by Perivascular Adipose Tissue. A Role in the Pathogenesis of Atherosclerosis?
Elvire Henrichot ;
From the Endocrine Unit, Department of Internal Medicine, University Hospital, Faculty of Medicine (E.H., C.E.J.-A., A.P., C.A.M.); Department of Cellular Physiology and Metabolism, Faculty of Medicine (E.H., C.E.J.-A., A.P., P.M., C.A.M.); Department of Pathology, Faculty of Medicine (J.-C.P.); Department of Cardiovascular Surgery, La Tour Hospital (V.V.); and the Division of Immunology and Allergy, Department of Internal Medicine, University Hospital, Faculty of Medicine (J.M.-D., C.C.), Geneva, Switzerland.
* To whom correspondence should be addressed. E-mail: Christoph.Meier{at}medecine.unige.ch.
Objective--Obesity is associated with an increased risk for cardiovascular disease. Although it is known that white adipose tissue (WAT) produces numerous proinflammatory and proatherogenic cytokines and chemokines, it is unclear whether adipose-derived chemotactic signals affect the chronic inflammation in atherosclerosis.
Methods and Results--Histological examination showed that perivascular WAT (pWAT) is in close proximity to vascular walls, particularly at sites of that have a tendency to develop atherosclerosis. In rodents, the amount of pWAT is markedly increased by a high-fat diet. At a functional level, supernatant from subcutaneous and pWAT strongly induced the chemotaxis of peripheral blood leukocytes. The migration of granulocytes and monocytes was mostly mediated by interleukin-8 and monocyte chemoattractant protein-1, respectively, whereas both chemokines contributed to the migration of activated T cells. Moreover, pWAT produces these chemokines, as shown by immunohistochemistry and by explant culture. The accumulation of macrophages and T cells at the interface between pWAT and the adventitia of human atherosclerotic aortas may reflect this prochemotactic activity of pWAT.
Conclusions--Human pWAT has chemotactic properties through the secretion of different chemokines, and we propose that pWAT might contribute to the progression of obesity-associated atherosclerosis.
Key words: chemokines • perivascular adipose tissue • chemotaxis • obesity • inflammation
This article has been cited by other articles:
 |
|
 |
|
  S. Apostolakis, K. Vogiatzi, V. Amanatidou, and D. A. Spandidos Interleukin 8 and cardiovascular disease Cardiovasc Res, December 1, 2009; 84(3): 353 - 360. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Takaoka, D. Nagata, S. Kihara, I. Shimomura, Y. Kimura, Y. Tabata, Y. Saito, R. Nagai, and M. Sata Periadventitial Adipose Tissue Plays a Critical Role in Vascular Remodeling Circ. Res., October 23, 2009; 105(9): 906 - 911. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. B. Police, S. E. Thatcher, R. Charnigo, A. Daugherty, and L. A. Cassis Obesity Promotes Inflammation in Periaortic Adipose Tissue and Angiotensin II-Induced Abdominal Aortic Aneurysm Formation Arterioscler Thromb Vasc Biol, October 1, 2009; 29(10): 1458 - 1464. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Starr, B. M. Evers, and H. Saito Age-Associated Increase in Cytokine Production During Systemic Inflammation: Adipose Tissue as a Major Source of IL-6 J Gerontol A Biol Sci Med Sci, July 1, 2009; 64A(7): 723 - 730. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. A. Payne, H. G. Bohlen, U. D. Dincer, L. Borbouse, and J. D. Tune Periadventitial adipose tissue impairs coronary endothelial function via PKC-{beta}-dependent phosphorylation of nitric oxide synthase Am J Physiol Heart Circ Physiol, July 1, 2009; 297(1): H460 - H465. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. T. Robinson and W. R. Taylor Beyond the Adventitia: Exploring the Outer Limits of the Blood Vessel Wall Circ. Res., February 27, 2009; 104(4): 416 - 418. [Full Text] [PDF]
|
|
|
|
|
|
T. K. Chatterjee, L. L. Stoll, G. M. Denning, A. Harrelson, A. L. Blomkalns, G. Idelman, F. G. Rothenberg, B. Neltner, S. A. Romig-Martin, E. W. Dickson, et al. Proinflammatory Phenotype of Perivascular Adipocytes: Influence of High-Fat Feeding Circ. Res., February 27, 2009; 104(4): 541 - 549. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Murdolo, C. Herder, Z. Wang, B. Rose, M. Schmelz, and P.-A. Jansson In situ profiling of adipokines in subcutaneous microdialysates from lean and obese individuals Am J Physiol Endocrinol Metab, November 1, 2008; 295(5): E1095 - E1105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. K. Surmi, R. D. Atkinson, M. L. Gruen, K. R. Coenen, and A. H. Hasty The role of macrophage leptin receptor in aortic root lesion formation Am J Physiol Endocrinol Metab, March 1, 2008; 294(3): E488 - E495. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. A. Rosito, J. M. Massaro, U. Hoffmann, F. L. Ruberg, A. A. Mahabadi, R. S. Vasan, C. J. O'Donnell, and C. S. Fox Pericardial Fat, Visceral Abdominal Fat, Cardiovascular Disease Risk Factors, and Vascular Calcification in a Community-Based Sample: The Framingham Heart Study Circulation, February 5, 2008; 117(5): 605 - 613. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Malinowski, M. A. Deja, K. S. Golba, T. Roleder, J. Biernat, and S. Wos Perivascular tissue of internal thoracic artery releases potent nitric oxide and prostacyclin-independent anticontractile factor Eur. J. Cardiothorac. Surg., February 1, 2008; 33(2): 225 - 231. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Gruen, M. Hao, D. W. Piston, and A. H. Hasty Leptin requires canonical migratory signaling pathways for induction of monocyte and macrophage chemotaxis Am J Physiol Cell Physiol, November 1, 2007; 293(5): C1481 - C1488. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Thalmann and C. A. Meier Local adipose tissue depots as cardiovascular risk factors Cardiovasc Res, September 1, 2007; 75(4): 690 - 701. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Matter and C. Handschin RANTES (Regulated on Activation, Normal T Cell Expressed and Secreted), Inflammation, Obesity, and the Metabolic Syndrome Circulation, February 27, 2007; 115(8): 946 - 948. [Full Text] [PDF]
|
|
|
|
|
|
H. Wu, S. Ghosh, X. D. Perrard, L. Feng, G. E. Garcia, J. L. Perrard, J. F. Sweeney, L. E. Peterson, L. Chan, C. W. Smith, et al. T-Cell Accumulation and Regulated on Activation, Normal T Cell Expressed and Secreted Upregulation in Adipose Tissue in Obesity Circulation, February 27, 2007; 115(8): 1029 - 1038. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Herder, J. Baumert, B. Thorand, S. Martin, H. Lowel, H. Kolb, and W. Koenig Chemokines and Incident Coronary Heart Disease: Results From the MONICA/KORA Augsburg Case-Cohort Study, 1984-2002 Arterioscler Thromb Vasc Biol, September 1, 2006; 26(9): 2147 - 2152. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Touyz Endothelial Cell IL-8, a New Target for Adiponectin: Implications in Vascular Protection Circ. Res., December 9, 2005; 97(12): 1216 - 1219. [Full Text] [PDF]
|
|