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Published Online
on August 25, 2005

Arteriosclerosis, Thrombosis, and Vascular Biology. 2005
Published online before print August 25, 2005, doi: 10.1161/01.ATV.0000183609.55154.44
A more recent version of this article appeared on November 1, 2005
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Submitted on April 20, 2005
Accepted on August 15, 2005

Mechanisms of Endothelial Differentiation in Embryonic Vasculogenesis

J. E. Ferguson III ; Rusty W. Kelley ; and Cam Patterson *

From the Carolina Cardiovascular Biology Center (J.E.F., R.W.K., C.P.) and the Departments of Medicine (C.P.), Pharmacology (J.E.F., C.P.), and Cell and Developmental Biology (C.P.), University of North Carolina, Chapel Hill, NC.

* To whom correspondence should be addressed. E-mail: cpatters{at}med.unc.edu.

Abstract--The formation of new blood vessels in the adult organism not only contributes to the progression of diseases such as cancer and diabetic retinopathy but also can be promoted in therapeutic approaches to various ischemic pathologies. Because many of the signals important to blood vessel development during embryogenesis are recapitulated during adult blood vessel formation, much work has been performed to better-understand the molecular control of endothelial differentiation in the developing embryo. In this review, we describe the current understanding of where endothelial differentiation from pluripotent progenitor cells occurs during development, how this process is controlled at the molecular level, and what model systems can be used to investigate the earliest steps of blood vessel formation.
Key words: development • endothelium • vasculogenesis • embryogenesis


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