on June 9, 2005
Published online before print June 9, 2005, doi: 10.1161/01.ATV.0000173308.13054.4f
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Submitted on September 7, 2004
Accepted on May 17, 2005
Association of the -92C/G and 807C/T Polymorphisms of the 
2 Subunit Gene With Human Platelets 2
1 Receptor Density
Nadine Ajzenberg *;
From the Departments of Hematology (N.A., P.D., M.-C.G.), Anesthesiology (C.B., I.P.), and Biochemistry (B.G.), the Clinical Investigation Center (V.H.), Biostatistics (P.V.), Hopital Bichat, AP-HP, and INSERM U698 (N.A., C.B., M.-C.G., J.B.), Hopital Bichat, University Paris, France.
* To whom correspondence should be addressed. E-mail: nadine.ajzenberg{at}bch.ap-hop-paris.fr.
Objective--Platelet adhesion to the subendothelial tissue via the collagen receptor 
2
1 is a crucial event in vascular biology. Although evidence has been provided that the number of platelets 21 copies is genetically determined, the molecular change primary responsible has not been yet elucidated. The aim of our present study was to investigate the effect of combined polymorphisms within both regulatory (-52C/T and -92C/G) and coding regions (807C/T and 1648A/G) of the 2 subunit gene on human platelets 21 receptor density and/or susceptibility to coronary artery disease (CAD).
Methods and Results--Among 254 cardiac surgery patients, no evidence was found for an association between the 2 subunit gene polymorphisms and CAD. In contrast, in a subgroup of 113 patients, we observed a significant association between all polymorphisms except -52C/T and 21 receptor level. Furthermore, when 3 groups of patients were defined according to the tertiles of platelets 21 copies, the -92C/807T haplotype was more frequent in the group of patients with high 21 receptor level.
Conclusion--These results suggest that an individual effect of each polymorphism located either in the coding or promoter sequence of the 2 gene may act in combination to modulate variations in platelets 21 receptor density.
Key words: -92C/G • 807C/T polymorphism •
21 density
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