on June 2, 2005
Published online before print June 2, 2005, doi: 10.1161/01.ATV.0000172660.24580.b4
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Submitted on October 25, 2004
Accepted on May 22, 2005
Reduced Immunoregulatory CD31+ T Cells in the Blood of Atherosclerotic Mice With Plaque Thrombosis
Giuseppina Caligiuri *;
From EMI0016 (G.C., A.A.H.Z., J.S., D.U., M.L., A.L.), Faculté de Médecine Paris, France; U681 (E.G., J.K.-L., A.-T.G., A.N.), Institut des Cordeliers, INSERM, Paris, France.
* To whom correspondence should be addressed. E-mail: giuseppina.Caligiuri{at}u430.bhdc.jussieu.fr.
Objective--Lymphocyte activation is thought to play a major role in the pathogenesis of atherosclerotic complications such as plaque thrombosis. Circulating CD31+ T cells have been shown to regulate human T cell activation. Aim of this study was to evaluate whether the proportion of circulating immunoregulatory CD31+ T cells is correlated to the occurrence of plaque thrombosis in aged apolipoprotein (apo) E knockout (KO) mice.
Methods and Results--CD31+ T cell depletion of spleen T cells enhanced proliferation (P<0.05) and interferon-
production (P<0.01) while reducing interleukin (IL)-4 (P<0.001) and IL-10 (P=0.001) secretion in response to minimally modified low-density lipoprotein. CD31+ T cells were counted in 65 apoE KO mice (46-week-old) by flow cytometry. Organizing thrombi could be documented in 28 of 195 (14%) lesions and in at least one of the aorta root lesions of 23 of 65 mice (35%). CD31+ T cell count was significantly reduced in mice showing plaque thrombosis (72.3±1.5% versus 84.1±1.2%; P<0.0001), but such reduction did not follow induced plaque rupture or experimentally controlled thrombosis.
Conclusions--Reduced CD31+ T cells in circulating blood is a hallmark of atherosclerotic plaque thrombosis. Our data suggest that CD31+ T cells may play an important regulatory role in the development of plaque thrombosis.
Key words: atherosclerosis • lymphocytes • thrombosis
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