on May 19, 2005
Arteriosclerosis, Thrombosis, and Vascular Biology. 2005
Published online before print May 19, 2005, doi: 10.1161/01.ATV.0000171155.05809.bf
Published online before print May 19, 2005, doi: 10.1161/01.ATV.0000171155.05809.bf
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Submitted on March 15, 2005
Accepted on May 9, 2005
Signaling of the Tissue Factor Coagulation Pathway in Angiogenesis and Cancer
Mattias Belting ;
From the Department of Immunology, The Scripps Research Institute, La Jolla, Calif. Current address for Mattias Belting is Lund University, Department of Oncology, BMC C13, SE-222 84, Lund, Sweden.
* To whom correspondence should be addressed. E-mail: ruf{at}scripps.edu.
Abstract--Activation of coagulation precedes or coincides with angiogenesis in wound healing and postischemic tissue regeneration. Advanced cancer is associated with a hypercoagulable state, and tissue factor expression by cancer cells has received widespread attention because of its significant contribution to the pathogenesis of cancer progression and metastasis. Our recent work demonstrates that tissue factor-mediated cellular signaling is relevant to cancer angiogenesis. Here we review the molecular mechanisms of tissue factor pathways in angiogenesis and tumorigenesis with emphasis on the intriguing role for tissue factor cytoplasmic domain signaling.
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