on May 12, 2005
Published online before print May 12, 2005, doi: 10.1161/01.ATV.0000170130.85334.38
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Submitted on October 15, 2004
Accepted on April 25, 2005
The Antiviral Cytomegalovirus-Inducible Gene 5 Is Expressed in Atherosclerosis and Regulated by Proinflammatory Agents
P. S. Olofsson *;
From the Center for Molecular Medicine (P.S.O., S.G., G.P.-B., C.S.-N., G.K.H.), Karolinska Institutet, Stockholm, Sweden; Division of Biomedicine (K.J., D.W., A.S.), Department of Caring Sciences, University of Örebro, Sweden; and Department of Vascular Surgery (U.H.), Karolinska Institutet, Stockholm, Sweden.
* To whom correspondence should be addressed. E-mail: Peder.Olofsson{at}cmm.ki.se.
Objective--Inflammatory processes play an important role in atherosclerosis, and increasing evidence implies that microbial pathogens and proinflammatory cytokines are involved in the development and activation of atherosclerotic lesions. To find new inflammatory genes, we explored the vascular transcriptional response to an activator of innate immunity bacterial lipopolysaccharides (LPSs).
Methods and Results--Gene arrays identified the cytomegalovirus-inducible gene 5 (cig5) among the genes most potently induced by LPS in human vascular biopsies. Cig5 was expressed by endothelial cells in atherosclerotic arteries and significantly elevated in atherosclerotic compared with normal arteries. In culture, cytomegalovirus infection, interferon-
, and LPS induced cig5 expression.
Conclusion--Cig5 is expressed in atherosclerosis and induced in vascular cells by inflammatory stimuli and cytomegalovirus infection. The putative functions of cig5 in atherosclerosis may relate to disease-associated microbes.
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