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on April 21, 2005

Arteriosclerosis, Thrombosis, and Vascular Biology. 2005
Published online before print April 21, 2005, doi: 10.1161/01.ATV.0000167520.41436.c0
A more recent version of this article appeared on July 1, 2005
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*Substance via MeSH
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*Aortic Aneurysm

Submitted on November 12, 2001
Accepted on April 8, 2005

High Prevalence of Circulating CD4+CD28- T-Cells in Patients With Small Abdominal Aortic Aneurysms

Christina Duftner ; Rüdiger Seiler ; Peter Klein-Weigel ; Heike Göbel ; Christian Goldberger ; Christian Ihling ; Gustav Fraedrich ; and Michael Schirmer *

From the Departments of Internal Medicine (C.D., C.G., M.S.) and Vascular Surgery (R.S., P.K.-W., G.F.), Innsbruck Medical University, Innsbruck, Austria; and the Department of Pathology (H.G., C.I.), University Hospital, Freiburg, Germany.

* To whom correspondence should be addressed. E-mail: michael.schirmer{at}uibk.ac.at.

Objective--To assess the possible role of proinflammatory CD28- T cells in abdominal aortic aneurysms (AAAs). Animal studies and human tissue studies suggest a role for interferon (IFN)-{gamma}-producing T cells in the development and progression of AAAs.

Methods and Results--Fluorescence-activated cells sorter analysis of peripheral blood samples and measurement of AAA size using sonography were performed in 101 AAA patients and 38 healthy controls. Peripheral percentages of CD28- T cells of the CD3+CD4+ and the CD3+CD8+ were enriched in AAA patients with 7.8±8.8% and 41.9±15.7% compared with healthy controls with 2.2±6.1% and 24.9±15.5%, respectively (P=0.002 and P<0.001, respectively). Both CD4+CD28- and CD8+CD28- T cells produced large amounts of IFN-{gamma} and perforin. Patients with small AAAs (<4 cm) showed higher peripheral levels of CD4+CD28- T cells than those with larger AAAs (P=0.025). Immunohistological examinations revealed 39.1±17.2% CD4+CD28- and 44.0±13.8% CD8+CD28- in AAA tissue specimens with inflammatory infiltrates.

Conclusions--IFN-{gamma}- and perforin-producing CD28- T cells are present in the periphery and the vessel wall of a majority of AAAs. This observation in humans favors the concept of a T cell-mediated pathophysiology of AAAs, especially during the early development of AAAs.
Key words: aortic disease • aneurysms • leukocytes • immune system • human




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