on March 24, 2005
Arteriosclerosis, Thrombosis, and Vascular Biology. 2005
Published online before print March 24, 2005, doi: 10.1161/01.ATV.0000163262.83456.6d
Published online before print March 24, 2005, doi: 10.1161/01.ATV.0000163262.83456.6d
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Submitted on January 23, 2005
Accepted on March 7, 2005
Myeloperoxidase and Cardiovascular Disease
Stephen J. Nicholls and Stanley L. Hazen *
From Departments of Cardiovascular Medicine and Cell Biology and Center for Cardiovascular Diagnostics and Prevention, Cleveland Clinic Foundation, Cleveland, Ohio.
* To whom correspondence should be addressed. E-mail: hazens{at}ccf.org.
Abstract--Myeloperoxidase (MPO) is a leukocyte-derived enzyme that catalyzes the formation of a number of reactive oxidant species. In addition to being an integral component of the innate immune response, evidence has emerged that MPO-derived oxidants contribute to tissue damage during inflammation. MPO-catalyzed reactions have been attributed to potentially proatherogenic biological activities throughout the evolution of cardiovascular disease, including during initiation, propagation, and acute complication phases of the atherosclerotic process. As a result, MPO and its downstream inflammatory pathways represent attractive targets for both prognostication and therapeutic intervention in the prophylaxis of atherosclerotic cardiovascular disease.
Key words: atherosclerosis • free radical • heart failure • high-density lipoprotein • low-density lipoprotein • myeloperoxidase • nitric oxide • scavenger receptor • vulnerable plaque
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