on November 29, 2004
Published online before print November 29, 2004, doi: 10.1161/01.ATV.0000151987.04607.24
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Submitted on June 16, 2004
Accepted on November 9, 2004
Effects of Exercise Training and Deconditioning on Platelet Aggregation Induced by Alternating Shear Stress in Men
Jong-Shyan Wang *;
From the Graduate Institute of Rehabilitation Science and Center for Gerontological Research (J.-S.W., Y.-S.L., Y.-W.C.), Chang Gung University, Taoyuan, Taiwan; Department of Pharmacology (J.-C.C.), Chang Gung University, Taoyuan, Taiwan.
* To whom correspondence should be addressed. E-mail: s5492{at}mail.cgu.edu.tw.
Objective--Alternating shear stress, which resembles the flow condition in stenotic arteries, induces platelet aggregation. This study investigated how exercise training and deconditioning influence alternating shear-induced platelet aggregation (ASIPA) and clarify the mechanisms underlying ASIPA.
Methods and Results-- Thirty healthy male sedentary subjects were randomly divided into control and trained groups. The trained men were trained on a bicycle ergometer at 
60% of maximal oxygen consumption for 30 minutes per day, 5 days per week for 8 weeks, and then were deconditioned for 8 weeks. The experimental results indicate the following: (1) short-term strenuous exercise increases the extent of ASIPA and is accompanied by increased the von Willebrand factor (vWF) binding and P-selectin expression on platelets in both the control and trained groups, whereas the enhancement of platelet function decreases after exercise training in trained subjects; (2) at rest and immediately after exercise, ASIPA and the vWF binding and P-selectin expression on platelets are reduced by training, but remain unchanged in the control group; and (3) deconditioning reverses the effects of training on resting and postexercise state.
Conclusions-- Exercise training suppresses the extent of ASIPA, probably by reducing vWF binding to platelets and P-selectin expression on platelets. However, deconditioning reverses the training effects.
Key words: training • detraining • shear stress • platelets • adhesion molecules
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