on November 29, 2004
Published online before print November 29, 2004, doi: 10.1161/01.ATV.0000151624.45775.13
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Submitted on September 28, 2004
Accepted on November 12, 2004
Tissue Factor-Factor VIIa Signaling
L. Vijaya Mohan Rao * and Usha R. Pendurthi
From the Biomedical Research Division, The University of Texas Health Center at Tyler, Tex.
* To whom correspondence should be addressed. E-mail: vijay.rao{at}uthct.edu.
Abstract--How does tissue factor (TF), whose principle role is to support clotting factor VIIa (FVIIa) in triggering the coagulation cascade, affect various pathophysiological processes? One of the answers is that TF interaction with FVIIa not only initiates the clotting but also induces cell signaling via activation of G-protein-coupled protease activated receptors (PARs). Recent studies using various cell model systems and limited in vivo systems are beginning to define how TF-VIIa-induced signaling regulates cellular behavior. Signaling pathways initiated by both TF-VIIa protease activation of PARs and phosphorylation of the TF-cytoplasmic domain appear to regulate cellular functions. In the present article, we review the emerging data on the mechanism of TF-mediated cell signaling and how it regulates various cellular responses, with particular focus on TF-VIIa protease-dependent signaling.
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