on October 28, 2004
Arteriosclerosis, Thrombosis, and Vascular Biology. 2004
Published online before print October 28, 2004, doi: 10.1161/01.ATV.0000149143.04821.eb
Published online before print October 28, 2004, doi: 10.1161/01.ATV.0000149143.04821.eb
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Submitted on September 27, 2004
Accepted on October 20, 2004
Redox Mechanisms in Blood Vessels
Cornelius F.H. Mueller ;
From Emory University Division of Cardiology, Department of Medicine and the Atlanta Veterans Administration Hospital, Atlanta, Ga.
* To whom correspondence should be addressed. E-mail: dharr02{at}emory.edu.
Abstract--Reactive oxygen species have been implicated in the pathogenesis of virtually every stage of vascular lesion formation, hypertension, and other vascular diseases. We are currently gaining insight into important sources of reactive oxygen species in the vessel wall, including the NADPH oxidases, xanthine oxidase, uncoupled nitric oxide synthase, and mitochondrial sources. Although various reactive oxygen species have pathological roles, some serve as important signaling molecules that modulate vascular tone, growth, and remodeling. In the next several months, a series of articles in Arteriosclerosis, Thrombosis, and Vascular Biology attempt to further elucidate how reactive oxygen species are produced by vascular cells and the roles of these in vascular homeostasis. This series promises to provide a valuable update on a wide variety of issues related to the biochemistry, molecular biology, and physiology of these important and fascinating molecules.
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