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Arteriosclerosis, Thrombosis, and Vascular Biology
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on October 21, 2004

Arteriosclerosis, Thrombosis, and Vascular Biology. 2004
Published online before print October 21, 2004, doi: 10.1161/01.ATV.0000148450.56697.4a
A more recent version of this article appeared on January 1, 2005
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*Compound via MeSH
*Substance via MeSH
Medline Plus Health Information
*Peripheral Arterial Disease

Submitted on July 12, 2004
Accepted on October 12, 2004

Vitamin D, Shedding Light on the Development of Disease in Peripheral Arteries

P. E. Norman and J. T. Powell *

From the School of Surgery and Pathology (P.E.N.), The University of Western Australia, Fremantle Hospital, Fremantle, Western Australia; and the Division of Surgery (J.T.P.), Anaesthesia and Intensive Care, Imperial College, London, UK.

* To whom correspondence should be addressed. E-mail: j.powell{at}imperial.ac.uk.

Abstract--Vitamin D is generally associated with calcium metabolism, especially in the context of uptake in the intestine and the formation and maintenance of bone. However, vitamin D influences a wide range of metabolic systems through both genomic and nongenomic pathways that have an impact on the properties of peripheral arteries. The genomic effects have wide importance for angiogenesis, elastogenesis, and immunomodulation; the nongenomic effects have mainly been observed in the presence of hypertension. Although some vitamin D is essential for cardiovascular health, excess may have detrimental effects, particularly on elastogenesis and inflammation of the arterial wall. Vitamin D is likely to have a role in the paradoxical association between arterial calcification and osteoporosis. This review explores the relationship between vitamin D and a range of physiological and pathological processes relevant to peripheral arteries.




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