on October 21, 2004
Published online before print October 21, 2004, doi: 10.1161/01.ATV.0000148322.89911.44
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on February 26, 2004
Accepted on October 11, 2004
Association of Lipoprotein-Associated Phospholipase A2 Mass and Activity With Calcified Coronary Plaque in Young Adults. The CARDIA Study
Carlos Iribarren *;
From the Division of Research (C.I., J.A.D., S.S.), Kaiser Permanente, Oakland, Calif; the Department of Laboratory Medicine and Pathology (M.D.G.), School of Medicine, University of Minnesota, Minneapolis; the Division of Epidemiology (M.D.G., D.R.J.), School of Public Health, University of Minnesota, Minneapolis; the Institute for Nutrition Research (D.R.J.), University of Oslo, Oslo, Norway; and National Institutes of Health/National Heart, Lung, and Blood Institute/DECA (C.L.), Epidemiology and Biometry Program, Bethesda, Md.
* To whom correspondence should be addressed. E-mail: cgi{at}dor.kaiser.org.
Objective--To examine the association of lipoprotein-associated phospholipase A2 (Lp-PLA2) mass and activity with calcified coronary plaque in young adults.
Methods and Results--Nested case-control study among CARDIA participants at the year 15 examination (2000 to 2001, 33 to 45 years old). Cases (n=266) were those with and controls (n=266) those without evidence of calcified coronary plaque by computed tomography matched 1:1 on sex and race. Lp-PLA2 mass and activity were significantly higher in cases (296±101 ng/mL and 36.4±12.3 nmol/min per minute) than in controls (267±80 ng/mL and 32.9±11.8 nmol/min per minute). In age-adjusted conditional logistic regression, the odds ratio (OR) of calcified coronary plaque per 1 standard deviation (SD) increment was 1.40 (95% CI, 1.17 to 1.67) and 1.39 (95% CI, 1.14 to 1.70) for Lp-PLA2 mass and activity, respectively. After adjusting for multiple covariates including low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides, and C-reactive protein, a statistically significant association remained for Lp-PLA2 mass (OR, 1.28; 95% CI, 1.03 to 1.60) but not for activity (OR, 1.09; 95% CI, 0.84 to 1.42). No evidence was found for interaction between Lp-PLA2 mass or activity with LDL-C as predictors of calcified coronary plaque.
Conclusion--An independent association of Lp-PLA2 mass with calcified coronary plaque existed in young adults. Therefore, Lp-PLA2 mass may be a useful marker of subclinical cardiovascular risk.
Key words: PLEASE • SUPPLY • KEY • WORDS
This article has been cited by other articles:
 |
|
 |
|
  M. S.V. Elkind, V. Leon, Y. P. Moon, M. C. Paik, and R. L. Sacco High-Sensitivity C-Reactive Protein and Lipoprotein-Associated Phospholipase A2 Stability Before and After Stroke and Myocardial Infarction Stroke, October 1, 2009; 40(10): 3233 - 3237. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Suzuki, C. Solomon, N. S. Jenny, R. Tracy, J. J. Nelson, B. M. Psaty, C. Furberg, and M. Cushman Lipoprotein-Associated Phospholipase A2 and Risk of Congestive Heart Failure in Older Adults: The Cardiovascular Health Study Circ Heart Fail, September 1, 2009; 2(5): 429 - 436. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. S. Brilakis, A. Khera, B. Saeed, S. Banerjee, D. K. McGuire, S. A. Murphy, and J. A. de Lemos Association of Lipoprotein-Associated Phospholipase A2 Mass and Activity with Coronary and Aortic Atherosclerosis: Findings from the Dallas Heart Study Clin. Chem., December 1, 2008; 54(12): 1975 - 1981. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Gardner, E. C. Reichert, M. K. Topham, and D. M. Stafforini Identification of a Domain That Mediates Association of Platelet-activating Factor Acetylhydrolase with High Density Lipoprotein J. Biol. Chem., June 20, 2008; 283(25): 17099 - 17106. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. B. Daniels, G. A. Laughlin, M. J. Sarno, R. Bettencourt, R. L. Wolfert, and E. Barrett-Connor Lipoprotein-associated phospholipase A2 is an independent predictor of incident coronary heart disease in an apparently healthy older population: the Rancho Bernardo Study. J. Am. Coll. Cardiol., March 4, 2008; 51(9): 913 - 919. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Winkler, M. M. Hoffmann, B. R. Winkelmann, I. Friedrich, G. Schafer, U. Seelhorst, B. Wellnitz, H. Wieland, B. O. Boehm, and W. Marz Lipoprotein-Associated Phospholipase A2 Predicts 5-Year Cardiac Mortality Independently of Established Risk Factors and Adds Prognostic Information in Patients with Low and Medium High-Sensitivity C-Reactive Protein (The Ludwigshafen Risk and Cardiovascular Health Study) Clin. Chem., August 1, 2007; 53(8): 1440 - 1447. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-D. Lee, D. R Jacobs Jr, P. J Schreiner, C. Iribarren, and A. Hankinson Abdominal obesity and coronary artery calcification in young adults: the Coronary Artery Risk Development in Young Adults (CARDIA) Study Am. J. Clinical Nutrition, July 1, 2007; 86(1): 48 - 54. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Lavi, J. P. McConnell, C. S. Rihal, A. Prasad, V. Mathew, L. O. Lerman, and A. Lerman Local Production of Lipoprotein-Associated Phospholipase A2 and Lysophosphatidylcholine in the Coronary Circulation: Association With Early Coronary Atherosclerosis and Endothelial Dysfunction in Humans Circulation, May 29, 2007; 115(21): 2715 - 2721. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Garza, V. M. Montori, J. P. McConnell, V. K. Somers, I. J. Kullo, and F. Lopez-Jimenez Association Between Lipoprotein-Associated Phospholipase A2 and Cardiovascular Disease: A Systematic Review Mayo Clin. Proc., February 1, 2007; 82(2): 159 - 165. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Iribarren, A. S. Go, G. Husson, S. Sidney, J. M. Fair, T. Quertermous, M. A. Hlatky, and S. P. Fortmann Metabolic Syndrome and Early-Onset Coronary Artery Disease: Is the Whole Greater Than Its Parts? J. Am. Coll. Cardiol., November 7, 2006; 48(9): 1800 - 1807. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. S. Jenny Lipoprotein-associated phospholipase A2: novel biomarker and causal mediator of atherosclerosis? Arterioscler Thromb Vasc Biol, November 1, 2006; 26(11): 2417 - 2418. [Full Text] [PDF]
|
|
|
|
|
|
W. Koenig, D. Twardella, H. Brenner, and D. Rothenbacher Lipoprotein-Associated Phospholipase A2 Predicts Future Cardiovascular Events in Patients With Coronary Heart Disease Independently of Traditional Risk Factors, Markers of Inflammation, Renal Function, and Hemodynamic Stress Arterioscler Thromb Vasc Biol, July 1, 2006; 26(7): 1586 - 1593. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. O'Donoghue, D. A. Morrow, M. S. Sabatine, S. A. Murphy, C. H. McCabe, C. P. Cannon, and E. Braunwald Lipoprotein-Associated Phospholipase A2 and Its Association With Cardiovascular Outcomes in Patients With Acute Coronary Syndromes in the PROVE IT-TIMI 22 (PRavastatin Or atorVastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction) Trial Circulation, April 11, 2006; 113(14): 1745 - 1752. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Kardys, H.-H. S. Oei, I. M. van der Meer, A. Hofman, M. M.B. Breteler, and J. C.M. Witteman Lipoprotein-Associated Phospholipase A2 and Measures of Extracoronary Atherosclerosis: The Rotterdam Study Arterioscler Thromb Vasc Biol, March 1, 2006; 26(3): 631 - 636. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Iribarren Lipoprotein-Associated Phospholipase A2 and Cardiovascular Risk: State of the Evidence and Future Directions Arterioscler Thromb Vasc Biol, January 1, 2006; 26(1): 5 - 6. [Full Text] [PDF]
|
|
|
|
|
|
I. Gazi, E. S. Lourida, T. Filippatos, V. Tsimihodimos, M. Elisaf, and A. D. Tselepis Lipoprotein-Associated Phospholipase A2 Activity Is a Marker of Small, Dense LDL Particles in Human Plasma Clin. Chem., December 1, 2005; 51(12): 2264 - 2273. [Abstract] [Full Text] [PDF]
|
|