on June 24, 2004
Published online before print June 24, 2004, doi: 10.1161/01.ATV.0000136649.83297.bf
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on March 29, 2004
Accepted on June 15, 2004
Genetic and Environmental Determinants of Fibrin Structure and Function. Relevance to Clinical Disease
Eleanor M Scott ;
From the Academic Unit of Molecular Vascular Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, UK.
* To whom correspondence should be addressed. E-mail: P.J.Grant{at}Leeds.ac.uk.
Abstract--The formation of a fibrin clot is one of the key events in atherothrombotic vascular disease. The structure of the fibrin clot and the genetic and environmental factors that modify it have effects on its biological function. Alterations in fibrin structure and function have implications for the clinical presentation of vascular disease. This review briefly describes the key features involved in the formation of a fibrin clot, its typical structure, and function. This is followed by a review of the current literature on genetic and environmental influences on fibrin structure/function and the relationship to clinical disease.
This article has been cited by other articles:
 |
|
 |
|
  A. Undas, I. Wiek, E. Stepien, K. Zmudka, and W. Tracz Hyperglycemia Is Associated With Enhanced Thrombin Formation, Platelet Activation, and Fibrin Clot Resistance to Lysis in Patients With Acute Coronary Syndrome Diabetes Care, August 1, 2008; 31(8): 1590 - 1595. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Undas, M. Kolarz, G. Kopec, and W. Tracz Altered fibrin clot properties in patients on long-term haemodialysis: relation to cardiovascular mortality Nephrol. Dial. Transplant., June 1, 2008; 23(6): 2010 - 2015. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Suntharalingam, K. Goldsmith, V. van Marion, L. Long, C. M. Treacy, F. Dudbridge, M. R. Toshner, J. Pepke-Zaba, J. C. J. Eikenboom, and N. W. Morrell Fibrinogen A{alpha} Thr312Ala polymorphism is associated with chronic thromboembolic pulmonary hypertension Eur. Respir. J., April 1, 2008; 31(4): 736 - 741. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. O. Pruissen, A. J. C. Slooter, F. R. Rosendaal, Y. van der Graaf, and A. Algra Coagulation factor XIII gene variation, oral contraceptives, and risk of ischemic stroke Blood, February 1, 2008; 111(3): 1282 - 1286. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Cerhan, S. M. Ansell, Z. S. Fredericksen, N. E. Kay, M. Liebow, T. G. Call, A. Dogan, J. M. Cunningham, A. H. Wang, W. Liu-Mares, et al. Genetic variation in 1253 immune and inflammation genes and risk of non-Hodgkin lymphoma Blood, December 15, 2007; 110(13): 4455 - 4463. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Zalewski, A. Undas, J. Godlewski, E. Stepien, and K. Zmudka No-Reflow Phenomenon After Acute Myocardial Infarction Is Associated With Reduced Clot Permeability and Susceptibility to Lysis Arterioscler. Thromb. Vasc. Biol., October 1, 2007; 27(10): 2258 - 2265. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Silveira and A. Hamsten Fibrin gel architecture influences endogenous fibrinolysis and may promote coronary artery disease. Arterioscler. Thromb. Vasc. Biol., November 1, 2006; 26(11): 2419 - 2420. [Full Text] [PDF]
|
|
|
|
|
|
J.P. Collet, Y. Allali, C. Lesty, M.L. Tanguy, J. Silvain, A. Ankri, B. Blanchet, R. Dumaine, J. Gianetti, L. Payot, et al. Altered Fibrin Architecture Is Associated With Hypofibrinolysis and Premature Coronary Atherothrombosis Arterioscler. Thromb. Vasc. Biol., November 1, 2006; 26(11): 2567 - 2573. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Undas, J. Brozek, M. Jankowski, Z. Siudak, A. Szczeklik, and H. Jakubowski Plasma Homocysteine Affects Fibrin Clot Permeability and Resistance to Lysis in Human Subjects Arterioscler. Thromb. Vasc. Biol., June 1, 2006; 26(6): 1397 - 1404. [Abstract] [Full Text] [PDF]
|
|