on June 24, 2004
Arteriosclerosis, Thrombosis, and Vascular Biology. 2004
Published online before print June 24, 2004, doi: 10.1161/01.ATV.0000136649.83297.bf
Published online before print June 24, 2004, doi: 10.1161/01.ATV.0000136649.83297.bf
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Submitted on March 29, 2004
Accepted on June 15, 2004
Genetic and Environmental Determinants of Fibrin Structure and Function. Relevance to Clinical Disease
Eleanor M Scott ;
From the Academic Unit of Molecular Vascular Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, UK.
* To whom correspondence should be addressed. E-mail: P.J.Grant{at}Leeds.ac.uk.
Abstract--The formation of a fibrin clot is one of the key events in atherothrombotic vascular disease. The structure of the fibrin clot and the genetic and environmental factors that modify it have effects on its biological function. Alterations in fibrin structure and function have implications for the clinical presentation of vascular disease. This review briefly describes the key features involved in the formation of a fibrin clot, its typical structure, and function. This is followed by a review of the current literature on genetic and environmental influences on fibrin structure/function and the relationship to clinical disease.
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