on June 17, 2004
Published online before print June 17, 2004, doi: 10.1161/01.ATV.0000136392.59656.8b
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on May 10, 2004
Accepted on June 10, 2004
Laminopathies and Atherosclerosis
Khalid Z. Al-Shali and Robert A. Hegele *
From the Robarts Research Institute and University of Western Ontario, London, Canada.
* To whom correspondence should be addressed. E-mail: hegele{at}robarts.ca.
Abstract--Laminopathies are genetic diseases that encompass a wide spectrum of phenotypes with diverse tissue pathologies and result mainly from mutations in the LMNA gene encoding nuclear lamin A/C. Some laminopathies affect the cardiovascular system, and a few (namely, Dunnigan-type familial partial lipodystrophy [FPLD2] and Hutchinson-Gilford progeria syndrome [HGPS]) feature atherosclerosis as a key component. The premature atherosclerosis of FPLD2 is probably related to characteristic proatherogenic metabolic disturbances such as dyslipidemia, hyperinsulinemia, hypertension, and diabetes. In contrast, the premature atherosclerosis of HGPS occurs with less exposure to metabolic proatherogenic traits and probably reflects the generalized process of accelerated aging in HGPS. Although some common polymorphisms of LMNA have been associated with traits related to atherosclerosis, the monogenic diseases FPLD2 and HGPS are more likely to provide clues about new pathways for the general process of atherosclerosis.
Key words: nuclear envelope • insulin resistance • aging • vascular disease • progeria
This article has been cited by other articles:
 |
|
 |
|
  M. Walter Interrelationships Among HDL Metabolism, Aging, and Atherosclerosis Arterioscler Thromb Vasc Biol, September 1, 2009; 29(9): 1244 - 1250. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Renard, G. Fourcade, D. Milhaud, D. Bessis, V. Esteves-Vieira, A. Boyer, P. Roll, P. Bourgeois, N. Levy, and A. De Sandre-Giovannoli Novel LMNA Mutation in Atypical Werner Syndrome Presenting With Ischemic Disease Stroke, February 1, 2009; 40(2): e11 - e14. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. C. Capell, F. S. Collins, and E. G. Nabel Mechanisms of Cardiovascular Disease in Accelerated Aging Syndromes Circ. Res., July 6, 2007; 101(1): 13 - 26. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. van der Veer, C. Ho, C. O'Neil, N. Barbosa, R. Scott, S. P. Cregan, and J. G. Pickering Extension of Human Cell Lifespan by Nicotinamide Phosphoribosyltransferase J. Biol. Chem., April 13, 2007; 282(15): 10841 - 10845. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Schwartz, Z. S. Galis, M. E. Rosenfeld, and E. Falk Plaque Rupture in Humans and Mice Arterioscler Thromb Vasc Biol, April 1, 2007; 27(4): 705 - 713. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Halaschek-Wiener and A. Brooks-Wilson Progeria of Stem Cells: Stem Cell Exhaustion in Hutchinson-Gilford Progeria Syndrome J. Gerontol. A Biol. Sci. Med. Sci., January 1, 2007; 62(1): 3 - 8. [Abstract] [Full Text] [PDF]
|
|