on June 17, 2004
Published online before print June 17, 2004, doi: 10.1161/01.ATV.0000135982.60383.48
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on April 30, 2004
Accepted on May 19, 2004
Circulating Oxidized Low-Density Lipoprotein and Its Association With Carotid Intima-Media Thickness in Asymptomatic Members of Familial Combined Hyperlipidemia Families
Ming-Lin Liu ;
From the Department of Medicine (M.-L.L., K.Y., M.-R.T.), Helsinki University Central Hospital, University of Helsinki, Finland; Research Institute of Public Health (R.S., J.T.S.), University of Kuopio, Finland; and Inner Savo Health Centre (J.T.S.), Suonenjoki, Finland.
* To whom correspondence should be addressed. E-mail: Marja-Riitta.Taskinen{at}helsinki.fi.
Objective--Oxidized low-density lipoprotein (Ox-LDL)is implicated in the pathogenesis of atherosclerosis. Circulating oxidation-specific epitopes on plasma Ox-LDL has been linked with coronary artery disease, but its determinants and its association with early development of atherosclerosis in familial combined hyperlipidemia (FCHL) has not been very well studied. This study aimed to investigate the determinants of the circulating Ox-LDL and the association between Ox-LDL and carotid intima-media thickness (IMT) in asymptomatic members of FCHL families.
Methods and Results--Ox-LDL, susceptibility of LDL to oxidation in vitro, plasma 8-isoprostane and antioxidants, lipids and lipoproteins, LDL particle size, and carotid IMT were measured in 150 asymptomatic FCHL family members. Affected FCHL family members had reduced LDL particle size and lag time for LDL oxidation, increased plasma levels of Ox-LDL, increased plasma urate and 
-tocopherol, and a trend for the increase of 8-isoprostane as compared with nonaffected FCHL. Ox-LDL was independently associated with serum LDL cholesterol, apoB, and 8-isoprostane in multivariate analysis but only univariately correlated with LDL particle size and lag time for LDL oxidation. In addition, Ox-LDL was significantly associated with carotid mean IMT independently of other clinical and biochemical variables in a multivariate model.
Conclusion--Serum LDL cholesterol, apoB levels, and 8-isoprostane were the most important determinants of Ox-LDL. Ox-LDL is independently associated with carotid IMT in asymptomatic FCHL family members and can be used as a marker of early atherosclerosis in FCHL.
Key words: carotid arteries • hyperlipoproteinemia • familial combined • lipoproteins • low-denisty lipoprotein • oxygen radical • ultrasonography
This article has been cited by other articles:
 |
|
 |
|
  F. Violi, V. Sanguigni, R. Carnevale, A. Plebani, P. Rossi, A. Finocchi, C. Pignata, D. De Mattia, B. Martire, M. C. Pietrogrande, et al. Hereditary Deficiency of gp91phox Is Associated With Enhanced Arterial Dilatation: Results of a Multicenter Study Circulation, October 20, 2009; 120(16): 1616 - 1622. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Flores-Mateo, P. Carrillo-Santisteve, R. Elosua, E. Guallar, J. Marrugat, J. Bleys, and M.-I. Covas Antioxidant Enzyme Activity and Coronary Heart Disease: Meta-analyses of Observational Studies Am. J. Epidemiol., July 15, 2009; 170(2): 135 - 147. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Langlois, E. R. Rietzschel, M. L. De Buyzere, D. De Bacquer, S. Bekaert, V. Blaton, G. G. De Backer, T. C. Gillebert, and on behalf of the Asklepios Investigators Femoral Plaques Confound the Association of Circulating Oxidized Low-Density Lipoprotein With Carotid Atherosclerosis in a General Population Aged 35 to 55 Years: The Asklepios Study Arterioscler Thromb Vasc Biol, August 1, 2008; 28(8): 1563 - 1568. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Castilla, A. Davalos, J. L. Teruel, F. Cerrato, M. Fernandez-Lucas, J. L. Merino, C. C. Sanchez-Martin, J. Ortuno, and M. A Lasuncion Comparative effects of dietary supplementation with red grape juice and vitamin E on production of superoxide by circulating neutrophil NADPH oxidase in hemodialysis patients Am. J. Clinical Nutrition, April 1, 2008; 87(4): 1053 - 1061. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Baba, N. Osakabe, Y. Kato, M. Natsume, A. Yasuda, T. Kido, K. Fukuda, Y. Muto, and K. Kondo Continuous intake of polyphenolic compounds containing cocoa powder reduces LDL oxidative susceptibility and has beneficial effects on plasma HDL-cholesterol concentrations in humans Am. J. Clinical Nutrition, March 1, 2007; 85(3): 709 - 717. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. G. Tsouli, D. N. Kiortsis, V. Xydis, M. I. Argyropoulou, M. Elisaf, and A. D. Tselepis Antibodies Against Various Forms of Mildly Oxidized Low-Density Lipoprotein Are Not Associated With Carotid Intima-Media Thickness in Patients With Primary Hyperlipidemia Angiology, October 1, 2006; 57(5): 615 - 622. [Abstract] [PDF]
|
|
|
|
 |
|
 S. Tsimikas, J. T. Willerson, and P. M. Ridker C-reactive protein and other emerging blood biomarkers to optimize risk stratification of vulnerable patients. J. Am. Coll. Cardiol., April 18, 2006; 47(8 Suppl): C19 - C31. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Sjogren, S. Basu, M. Rosell, A. Silveira, U. de Faire, B. Vessby, A. Hamsten, M.-L. Hellenius, and R. M. Fisher Measures of Oxidized Low-Density Lipoprotein and Oxidative Stress Are Not Related and Not Elevated in Otherwise Healthy Men With the Metabolic Syndrome Arterioscler Thromb Vasc Biol, December 1, 2005; 25(12): 2580 - 2586. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Cesari, S. B. Kritchevsky, B. J. Nicklas, B. W. H. J. Penninx, P. Holvoet, P. Koh-Banerjee, S. R. Cummings, T. B. Harris, A. B. Newman, and M. Pahor Lipoprotein Peroxidation and Mobility Limitation: Results From the Health, Aging, and Body Composition Study Arch Intern Med, October 10, 2005; 165(18): 2148 - 2154. [Abstract] [Full Text] [PDF]
|
|