on June 3, 2004
Published online before print June 3, 2004, doi: 10.1161/01.ATV.0000134294.54422.2e
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Submitted on April 22, 2004
Accepted on May 6, 2004
IL-8 Plasma Concentrations and the Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women. The EPIC-Norfolk Prospective Population Study
S. Matthijs Boekholdt ;
From the Department of Cardiology (S.M.B., R.J.G.P.), Laboratory for Experimental Internal Medicine (P.H.R.), Academic Medical Center, Amsterdam, the Netherlands; Department of Public Health and Primary Care (N.E.D., R.L., N.J.W., K.T.K.), Institute of Public Health, University of Cambridge, Cambridge, United Kingdom; Medical Research Council Dunn Nutrition Unit (S.A.B.), Cambridge, United Kingdom; Sanquin Research at the Central Laboratory of the Blood Transfusion Service (C.E.H), Amsterdam, the Netherlands.
* To whom correspondence should be addressed. E-mail: kk101{at}medschl.cam.ac.uk.
Objective--To study the role of IL-8 in predicting future coronary artery disease (CAD) in apparently healthy men and women.
Methods and Results--A nested case-control study was performed in the prospective EPIC-Norfolk population study. We measured baseline IL-8 concentrations among 785 apparently healthy individuals in whom fatal or nonfatal CAD developed during follow-up and 1570 matched controls. Baseline IL-8 concentrations were higher in cases than in matched controls (3.5 pg/mL versus 3.1 pg/mL, P=0.001). The risk of future CAD increased with increasing quartiles of IL-8 (P linearity <0.0001). Among individuals in the highest IL-8 quartile, the unadjusted odds ratio for future CAD was 1.72 (95% CI, 1.34 to 2.21; P<0.0001). The odds ratio for future CAD was still significant after adjustment for traditional risk factors (OR, 1.58; 95%CI, 1.19 to 2.09; P=0.002) and after additional adjustment for C-reactive protein and white cell count (OR, 1.77; 95% CI, 1.21 to 2.60; P=0.001).
Conclusions--We conclude that among apparently healthy men and women, elevated levels of IL-8 are associated with an increased risk of future CAD. These prospective data support a role for IL-8 in the development of CAD events.
Key words: IL-8 • cytokines • coronary artery disease
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