on April 22, 2004
Arteriosclerosis, Thrombosis, and Vascular Biology. 2004
Published online before print April 22, 2004, doi: 10.1161/01.ATV.0000128897.54893.26
Published online before print April 22, 2004, doi: 10.1161/01.ATV.0000128897.54893.26
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Submitted on February 17, 2004
Accepted on April 8, 2004
Cardiovascular Biology of the Asymmetric Dimethylarginine:Dimethylarginine Dimethylaminohydrolase Pathway
Patrick Vallance * and James Leiper
From the BHF Laboratories, Division of Medicine.
* To whom correspondence should be addressed. E-mail: patrick.valance{at}ucl.ac.uk.
Abstract--An increasing number of reports indicate that endogenously produced inhibitors of nitric oxide synthase, particularly asymmetric dimethylarginine (ADMA), regulate nitric oxide generation in disease states. This article describes the biology of ADMA and the implications for cardiovascular physiology and pathophysiology.
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