Donate Help Contact The AHA Sign In Home
American Heart Association
Arteriosclerosis, Thrombosis, and Vascular Biology
Search: search_blue_button Advanced Search
Published Online
on February 26, 2004

Arteriosclerosis, Thrombosis, and Vascular Biology. 2004
Published online before print February 26, 2004, doi: 10.1161/01.ATV.0000124104.23702.a0
A more recent version of this article appeared on April 1, 2004
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
24/4/684    most recent
01.ATV.0000124104.23702.a0v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Adams, V.
Right arrow Articles by Hambrecht, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Adams, V.
Right arrow Articles by Hambrecht, R.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Related Collections
Right arrow Angiogenesis
Right arrow Other Vascular biology

Submitted on January 14, 2004
Accepted on January 24, 2004

Increase of Circulating Endothelial Progenitor Cells in Patients With Coronary Artery Disease After Exercise-Induced Ischemia

Volker Adams *; Karsten Lenk ; Axel Linke ; Dominik Lenz ; Sandra Erbs ; Markus Sandri ; Attila Tarnok ; Stephan Gielen ; Frank Emmrich ; Gerhard Schuler ; and Rainer Hambrecht

From University Leipzig (V.A., K.L., S.E., M.S., S.G., G.S., R.H.), Heart Center Leipzig, Clinic of Cardiology, and Pediatric Cardiology (D.L., A.T.), Germany; and Institute of Clinical Immunology and Transfusion Medicine (F.E.) University Leipzig, Germany.

* To whom correspondence should be addressed. E-mail: adav{at}medizin.uni-leipzig.de.

Objectives--The concept of neovascularization in response to tissue ischemia has been extended by the finding of postnatal vasculogenesis initiated by endothelial progenitor cells (EPCs). The aim of this study was to analyze whether a maximal stress test in patients with coronary artery disease (CAD) increases the number of circulating EPCs.

Methods and Results--Blood concentration of EPCs was analyzed by FACS and cell culture assay in CAD patients with (n=16) or without (n=12) exercise-induced myocardial ischemia and in healthy subjects (n=11) for up to 144 hours after maximal stress test. Plasma concentrations of vascular endothelial growth factor (VEGF), basic fibroblast growth factor, tumor necrosis factor-{alpha}, and granulocyte macrophage-colony stimulating factor were determined by ELISA. EPCs increased significantly in ischemic patients, with a maximum after 24 to 48 hours (cell culture: 3.3±0.5-fold increase; FACS: 3.1±0.6-fold increase) and returned to baseline within 72 hour. In nonischemic patients and healthy subjects, no EPC increase was detectable. VEGF levels in ischemic patients increased significantly after 2 to 6 hours (maximum after 2 hours; 4.0±1.1-fold increase) and no change was observed in nonischemic patients and healthy subjects; {Delta}VEGF and {Delta}EPC correlated significantly (r=0.66).

Conclusions--Patients with symptomatic CAD respond to a single episode of exercise-induced myocardial ischemia with a time-dependent increase in circulating EPCs. This increase may be related to and preceded by an increase in plasma VEGF.




This article has been cited by other articles:


Home page
 Clin. Cancer Res.Home page
K. Bogos, F. Renyi-Vamos, J. Dobos, J. Tovari, G. Ostoros, and B. Dome

Clin. Cancer Res., November 1, 2009; 15(21): 6740 - 6741.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. D. Baker, S. L. Ryan, D. A. Ingram, G. J. Seedorf, S. H. Abman, and V. Balasubramaniam
Endothelial Colony-forming Cells from Preterm Infants Are Increased and More Susceptible to Hyperoxia
Am. J. Respir. Crit. Care Med., September 1, 2009; 180(5): 454 - 461.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
B-C Lee, H-C Hsu, W-Y I Tseng, M-Y M Su, S-Y Chen, Y-W Wu, K-L Chien, and M-F Chen
Effect of cardiac rehabilitation on angiogenic cytokines in postinfarction patients
Heart, June 15, 2009; 95(12): 1012 - 1018.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
A. M. Leone, M. Valgimigli, M. B. Giannico, V. Zaccone, M. Perfetti, D. D'Amario, A. G. Rebuzzi, and F. Crea
From bone marrow to the arterial wall: the ongoing tale of endothelial progenitor cells
Eur. Heart J., April 2, 2009; 30(8): 890 - 899.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
J.-L. Balligand, O. Feron, and C. Dessy
eNOS Activation by Physical Forces: From Short-Term Regulation of Contraction to Chronic Remodeling of Cardiovascular Tissues
Physiol Rev, April 1, 2009; 89(2): 481 - 534.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Sports. Med.Home page
A Schmidt, S Bierwirth, S Weber, P Platen, T Schinkothe, and W Bloch
Short intensive exercise increases the migratory activity of mesenchymal stem cells
Br. J. Sports Med., March 1, 2009; 43(3): 195 - 198.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Sports. Med.Home page
A Lucia, A De La Rosa, M A. Silvan, L M Lopez-Mojares, A Boraita, M Perez, C Foster, J Garcia-Castro, and M Ramirez
Mobilisation of mesenchymal cells in cardiac patients: is intense exercise necessary?
Br. J. Sports Med., March 1, 2009; 43(3): 221 - 223.
[Abstract] [Full Text] [PDF]

Home page
 ANGIOLOGYHome page
I. Al Mheid and A. A. Quyyumi
Cell Therapy in Peripheral Arterial Disease
Angiology, January 1, 2009; 59(6): 705 - 716.
[Abstract] [PDF]

Home page
 Nephrol Dial TransplantHome page
A. Surdacki, E. Marewicz, E. Wieteska, G. Szastak, T. Rakowski, E. Wieczorek-Surdacka, D. Dudek, J. Pryjma, and J. S. Dubiel
Association between endothelial progenitor cell depletion in blood and mild-to-moderate renal insufficiency in stable angina
Nephrol. Dial. Transplant., July 1, 2008; 23(7): 2265 - 2273.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
M. Thill, N. V. Strunnikova, M. J. Berna, N. Gordiyenko, K. Schmid, S. W. Cousins, D. J. S. Thompson, and K. G. Csaky
Late Outgrowth Endothelial Progenitor Cells in Patients with Age-Related Macular Degeneration
Invest. Ophthalmol. Vis. Sci., June 1, 2008; 49(6): 2696 - 2708.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
K. Kendziorra, H. Barthel, S. Erbs, F. Emmrich, R. Hambrecht, G. Schuler, O. Sabri, and R. Kluge
Effect of Progenitor Cells on Myocardial Perfusion and Metabolism in Patients After Recanalization of a Chronically Occluded Coronary Artery
J. Nucl. Med., April 1, 2008; 49(4): 557 - 563.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Sports. Med.Home page
K Brixius, S Schoenberger, D Ladage, H Knigge, G Falkowski, M Hellmich, C Graf, J Latsch, G l Montie, G l Prede, et al.
Long-term endurance exercise decreases antiangiogenic endostatin signalling in overweight men aged 50-60 years
Br. J. Sports Med., February 1, 2008; 42(2): 126 - 129.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
H.-K. Yip, L.-T. Chang, W.-N. Chang, C.-H. Lu, C.-W. Liou, M.-Y. Lan, J. S. Liu, A. A. Youssef, and H.-W. Chang
Level and Value of Circulating Endothelial Progenitor Cells in Patients After Acute Ischemic Stroke
Stroke, January 1, 2008; 39(1): 69 - 74.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
J. Tongers and D. W. Losordo
Frontiers in Nephrology: The Evolving Therapeutic Applications of Endothelial Progenitor Cells
J. Am. Soc. Nephrol., November 1, 2007; 18(11): 2843 - 2852.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
C. Werner, C. H. Kamani, C. Gensch, M. Bohm, and U. Laufs
The Peroxisome Proliferator Activated Receptor-{gamma} Agonist Pioglitazone Increases Number and Function of Endothelial Progenitor Cells in Patients With Coronary Artery Disease and Normal Glucose Tolerance
Diabetes, October 1, 2007; 56(10): 2609 - 2615.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
H. Shmilovich, V. Deutsch, A. Roth, H. Miller, G. Keren, and J. George
Circulating endothelial progenitor cells in patients with cardiac syndrome X
Heart, September 1, 2007; 93(9): 1071 - 1076.
[Abstract] [Full Text] [PDF]

Home page
 Vasc MedHome page
R. G. Shaffer, S. Greene, A. Arshi, G. Supple, A. Bantly, J. S Moores, M. S Parmacek, and E. R Mohler III
Effect of acute exercise on endothelial progenitor cells in patients with peripheral arterial disease
Vascular Medicine, November 1, 2006; 11(4): 219 - 226.
[Abstract] [PDF]

Home page
 J Am Coll CardiolHome page
C. J. Boos, G. Y.H. Lip, and A. D. Blann
Circulating Endothelial Cells in Cardiovascular Disease
J. Am. Coll. Cardiol., October 17, 2006; 48(8): 1538 - 1547.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
J. Leor and M. Marber
Endothelial Progenitors: A New Tower of Babel?
J. Am. Coll. Cardiol., October 17, 2006; 48(8): 1588 - 1590.
[Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
H. Guven, R. M. Shepherd, R. G. Bach, B. J. Capoccia, and D. C. Link
The Number of Endothelial Progenitor Cell Colonies in the Blood Is Increased in Patients With Angiographically Significant Coronary Artery Disease
J. Am. Coll. Cardiol., October 17, 2006; 48(8): 1579 - 1587.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B. Dome, J. Timar, J. Dobos, L. Meszaros, E. Raso, S. Paku, I. Kenessey, G. Ostoros, M. Magyar, A. Ladanyi, et al.
Identification and clinical significance of circulating endothelial progenitor cells in human non-small cell lung cancer.
Cancer Res., July 15, 2006; 66(14): 7341 - 7347.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
D. Patschan, K. Krupincza, S. Patschan, Z. Zhang, C. Hamby, and M. S. Goligorsky
Dynamics of mobilization and homing of endothelial progenitor cells after acute renal ischemia: modulation by ischemic preconditioning
Am J Physiol Renal Physiol, July 1, 2006; 291(1): F176 - F185.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
S. Erbs, A. Linke, V. Adams, K. Lenk, H. Thiele, K.-W. Diederich, F. Emmrich, R. Kluge, K. Kendziorra, O. Sabri, et al.
Transplantation of Blood-Derived Progenitor Cells After Recanalization of Chronic Coronary Artery Occlusion: First Randomized and Placebo-Controlled Study
Circ. Res., October 14, 2005; 97(8): 756 - 762.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
M. Ruel, E. J. Suuronen, J. Song, V. Kapila, D. Gunning, G. Waghray, F. D. Rubens, and T. G. Mesana
Effects of off-pump versus on-pump coronary artery bypass grafting on function and viability of circulating endothelial progenitor cells
J. Thorac. Cardiovasc. Surg., September 1, 2005; 130(3): 633 - 639.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart J SupplHome page
P. Gabriel Steg and D. Himbert
Unmet medical needs and therapeutic opportunities in stable angina
Eur. Heart J. Suppl., September 1, 2005; 7(suppl_H): H7 - H15.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
M. Massa, V. Rosti, I. Ramajoli, R. Campanelli, A. Pecci, G. Viarengo, V. Meli, M. Marchetti, R. Hoffman, and G. Barosi
Circulating CD34+, CD133+, and Vascular Endothelial Growth Factor Receptor 2-Positive Endothelial Progenitor Cells in Myelofibrosis With Myeloid Metaplasia
J. Clin. Oncol., August 20, 2005; 23(24): 5688 - 5695.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
M. Sandri, V. Adams, S. Gielen, A. Linke, K. Lenk, N. Krankel, D. Lenz, S. Erbs, D. Scheinert, F. W. Mohr, et al.
Effects of Exercise and Ischemia on Mobilization and Functional Activation of Blood-Derived Progenitor Cells in Patients With Ischemic Syndromes: Results of 3 Randomized Studies
Circulation, June 28, 2005; 111(25): 3391 - 3399.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Loeffler, J. A. Kruger, and R. A. Reisfeld
Immunostimulatory Effects of Low-Dose Cyclophosphamide Are Controlled by Inducible Nitric Oxide Synthase
Cancer Res., June 15, 2005; 65(12): 5027 - 5030.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
N. Krankel, V. Adams, A. Linke, S. Gielen, S. Erbs, K. Lenk, G. Schuler, and R. Hambrecht
Hyperglycemia Reduces Survival and Impairs Function of Circulating Blood-Derived Progenitor Cells
Arterioscler Thromb Vasc Biol, April 1, 2005; 25(4): 698 - 703.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
A. Aicher, A. M. Zeiher, and S. Dimmeler
Mobilizing Endothelial Progenitor Cells
Hypertension, March 1, 2005; 45(3): 321 - 325.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
G. Schatteman
Are Circulating CD133+ Cells Biomarkers of Vascular Disease?
Arterioscler Thromb Vasc Biol, February 1, 2005; 25(2): 270 - 271.
[Full Text] [PDF]

Home page
 Circ. Res.Home page
M. Kucia, B. Dawn, G. Hunt, Y. Guo, M. Wysoczynski, M. Majka, J. Ratajczak, F. Rezzoug, S. T. Ildstad, R. Bolli, et al.
Cells Expressing Early Cardiac Markers Reside in the Bone Marrow and Are Mobilized Into the Peripheral Blood After Myocardial Infarction
Circ. Res., December 10, 2004; 95(12): 1191 - 1199.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
D. Perera, G. Kanaganayagam, and M. Marber
Stem cells in unstable angina: the dynamic duo
Eur. Heart J., June 2, 2004; 25(12): 999 - 1000.
[Full Text] [PDF]


ATVB Home | Subscriptions | Archives | Feedback | Authors | Help | AHA Journals Home | Search
Copyright © 2004 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited.