on December 29, 2003
Arteriosclerosis, Thrombosis, and Vascular Biology. 2003
Published online before print December 29, 2003, doi: 10.1161/01.ATV.0000114236.77009.06
Published online before print December 29, 2003, doi: 10.1161/01.ATV.0000114236.77009.06
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Submitted on November 16, 2003
Accepted on November 19, 2003
Characterization of Two Types of Endothelial Progenitor Cells and Their Different Contributions to Neovasculogenesis
Jin Hur ;
From the Cardiovascular Laboratory (J.H., C.-H.Y., H.-S.K., J.-H.C., H.-J.K., K.-K.H.), Clinical Research Institute, Seoul National University Hospital, Korea; and the Department of Internal Medicine (J.H., C.-H.Y., H.-S.K., J.-H.C., H.-J.K., K.-K.H., B.-H.O., M.-M.L., Y.-B.P.), Seoul National University College of Medicine, Seoul, Korea.
* To whom correspondence should be addressed. E-mail: hyosoo{at}snu.ac.kr.
Objective--Endothelial progenitor cells (EPC) in one study group is not the same as EPC in other investigators, suggesting that EPC is not a single type of cell population. In this study, we tried to demonstrate the heterogeneity of EPC.
Methods and Results--We cultured total mononuclear cells from human peripheral blood to get two types of EPC sequentially from the same donors. We called them early EPC and late EPC. Early EPC with spindle shape showed peak growth at 2 to 3 weeks and died at 4 weeks, whereas late EPC with cobblestone shape appeared late at 2 to 3 weeks, showed exponential growth at 4 to 8 weeks, and lived up to 12 weeks. Late EPC was different from early EPC in the expression of VE-cadherin, Flt-1, KDR, and CD45. Late EPC produced more nitric oxide, incorporated more readily into human umbilical vein endothelial cells monolayer, and formed capillary tube better than early EPC. Early EPC secreted angiogenic cytokines (vascular endothelial growth factor, interleukin 8) more so than late EPC during culture in vitro. Both types of EPC showed comparable in vivo vasculogenic capacity.
Conclusions--We found two types of EPC from a source of adult peripheral blood that might have different roles in neovasculogenesis based on the identified differences.
Key words: stem cells • endothelial progenitor cell • endothelial cell • angiogenesis • cell therapy
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D. A. Ingram, L. E. Mead, D. B. Moore, W. Woodard, A. Fenoglio, and M. C. Yoder Vessel wall-derived endothelial cells rapidly proliferate because they contain a complete hierarchy of endothelial progenitor cells Blood, April 1, 2005; 105(7): 2783 - 2786. [Abstract] [Full Text] [PDF]
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J.-H. Choi, J. Hur, C.-H. Yoon, J.-H. Kim, C.-S. Lee, S.-W. Youn, I.-Y. Oh, C. Skurk, T. Murohara, Y.-B. Park, et al. Augmentation of Therapeutic Angiogenesis Using Genetically Modified Human Endothelial Progenitor Cells with Altered Glycogen Synthase Kinase-3{beta} Activity J. Biol. Chem., November 19, 2004; 279(47): 49430 - 49438. [Abstract] [Full Text] [PDF]
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D. A. Ingram, L. E. Mead, H. Tanaka, V. Meade, A. Fenoglio, K. Mortell, K. Pollok, M. J. Ferkowicz, D. Gilley, and M. C. Yoder Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood Blood, November 1, 2004; 104(9): 2752 - 2760. [Abstract] [Full Text] [PDF]
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L. Biancone, V. Cantaluppi, D. Duo, M. C. Deregibus, C. Torre, and G. Camussi Role of L-Selectin in the Vascular Homing of Peripheral Blood-Derived Endothelial Progenitor Cells J. Immunol., October 15, 2004; 173(8): 5268 - 5274. [Abstract] [Full Text] [PDF]
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T. He, L. A. Smith, S. Harrington, K. A. Nath, N. M. Caplice, and Z. S. Katusic Transplantation of Circulating Endothelial Progenitor Cells Restores Endothelial Function of Denuded Rabbit Carotid Arteries Stroke, October 1, 2004; 35(10): 2378 - 2384. [Abstract] [Full Text] [PDF]
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C. Urbich and S. Dimmeler Endothelial Progenitor Cells: Characterization and Role in Vascular Biology Circ. Res., August 20, 2004; 95(4): 343 - 353. [Abstract] [Full Text] [PDF]
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