on December 4, 2003
Published online before print December 4, 2003, doi: 10.1161/01.ATV.0000110657.67317.90
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Submitted on October 3, 2003
Accepted on November 21, 2003
Growth Hormone Induces Low-Density Lipoprotein Clearance but not Bile Acid Synthesis in Humans
Suzanne Lind ;
From the Metabolism Unit (S.L., M.R., S.E., H.O., M.E., B.A.), Center for Metabolism and Endocrinology, Department of Medicine and Molecular Nutrition Unit, Center for Nutrition and Toxicology, Novum; Division of Clinical Chemistry (S.L., G.E., L.B.), Department of Laboratory Medicine; and Pediatric Unit (B.B.), Department of Clinical Sciences, Karolinska Institute at Huddinge University Hospital, Stockholm, Sweden.
* To whom correspondence should be addressed. E-mail: bo.angelin{at}medhs.ki.se.
Objective--Growth hormone (GH) induces hepatic low-density lipoprotein (LDL) receptors and lowers plasma cholesterol. We characterized the influence of GH treatment on plasma LDL clearance in normal humans and investigated the relative role of LDL receptor (LDLR) activity and stimulation of bile acid synthesis in subjects with different LDLR expression.
Methods and Results--Plasma clearance of autologous 125I-LDL was measured before and during 3 weeks of treatment with GH (0.1 IU/kg per day) in 9 healthy young males. Plasma LDL cholesterol was reduced by 13% and the fractional catabolic rate of LDL increased by 27%. More marked changes were seen in a patient with hypopituitarism substituted with GH (0.07 IU/kg per day) for 3 months. In a second study, GH dose-dependently reduced LDL cholesterol and increased Lp(a) levels in 3 groups of males: younger and elderly healthy subjects and heterozygous familial hypercholesterolemia (FH). No effect on bile acid synthesis measured by the plasma marker 7
-hydroxy-4-cholesten-3-one was observed. In LDLR-deficient FH homozygote, LDL cholesterol was not affected by GH.
Conclusions--GH treatment reduces plasma LDL cholesterol by inducing LDL clearance. In humans, LDLR expression is a prerequisite for this effect, although it is not related to stimulation of bile acid synthesis.
Key words: insulin-like growth factor-I • low density lipoprotein kinetics • familial hypercholesterolemia • lipoprotein (a)
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