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on October 9, 2003

Arteriosclerosis, Thrombosis, and Vascular Biology. 2003
Published online before print October 9, 2003, doi: 10.1161/01.ATV.0000099786.99623.EF
A more recent version of this article appeared on January 1, 2004
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Submitted on May 27, 2003
Accepted on August 26, 2003

Adiponectin and Metabolic Syndrome

Yuji Matsuzawa *; Tohru Funahashi ; Shinji Kihara ; and Iichiro Shimomura

From the Department of Internal Medicine and Molecular Science, Osaka University Graduate School, Sumitomo Hospital, Osaka, Japan.

* To whom correspondence should be addressed. E-mail: matsuzawa-yuki{at}sumitomo-hp.or.jp.

Abstract--In this review article, the crucial roles of adipocytes in the development of so-called metabolic syndrome and vascular disease are reviewed, focusing on adipocyte-derived bioactive substances, adipocytokines. Recent progress in adipocyte biology shows that adipocytes are not merely energy-storing cells but that they secrete a variety of hormones cytokines, growth factors, and other bioactive substances. To search for novel adipocytokines by the large-scale random sequence analysis of expressed genes in adipocytes, we identified an adipose-specific collagen-like molecule, adiponectin. This novel adipocytokine has plural biofunctions, such as antidiabetic, antiatherosclerotic, and antiinflammatory functions. Adiponectin plasma levels decrease with the accumulation of visceral adipose tissue. In this review, we discuss the link of adiponectin to visceral adiposity, insulin resistance, and vascular diseases.




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