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Published Online
on September 4, 2003

Arteriosclerosis, Thrombosis, and Vascular Biology. 2003
Published online before print September 4, 2003, doi: 10.1161/01.ATV.0000093547.63630.0F
A more recent version of this article appeared on October 1, 2003
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Submitted on June 13, 2003
Accepted on August 19, 2003

Mineral Exploration: Search for the Mechanism of Vascular Calcification and Beyond. The 2003 Jeffrey M. Hoeg Award Lecture

Linda L. Demer * and Yin Tintut

From the Departments of Medicine (L.L.D.) and Physiology (Y.T.), The David Geffen School of Medicine at University of California Los Angeles, Calif.

Abstract--Research in the area of vascular calcification has grown rapidly in the past decade, and there is a greater understanding of its active regulatory mechanisms. This brief review covers the ideas presented in the 2003 Jeffrey M. Hoeg Award lecture, including the concepts that bone tissue forms in the artery wall in patients with atherosclerosis, that vascular cells undergo osteoblastic differentiation, that bone morphogenetic protein and matrix GLA protein regulate vascular calcification in opposition, that inflammatory cytokines and lipids promote vascular cell calcification but inhibit osteoblastic cell differentiation, that these same factors promote differentiation of bone-resorbing osteoclasts, and that the artery wall may contain osteoclast-like cells with the potential to resorb calcium mineral. The review closes with a mention of therapeutic possibilities and an evolutionary paradigm to explain the reciprocal responses of vascular and bone mineralization to inflammation.
Key words: calcification • vascular • smooth muscle • differentiation • bone




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