on April 24, 2003
Published online before print April 24, 2003, doi: 10.1161/01.ATV.0000072969.71452.87
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Submitted on February 2, 2003
Accepted on March 28, 2003
Antibodies to Periodontal Pathogens Are Associated With Coronary Heart Disease
Pirkko J. Pussinen *;
From the Institute of Dentistry, University of Helsinki and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital (P.J.P., S.A.), Finland; Umeå University (S.A.), Sweden; and Department of Epidemiology and Health Promotion (P.J., V.S.) and Department of Health and Functional Ability (G.A., T.P.), KTL-National Public Health Institute, Helsinki, Finland.
* To whom correspondence should be addressed. E-mail: pirkko.pussinen{at}helsinki.fi.
Objective--We analyzed the association of coronary heart disease (CHD) and serology of periodontitis in a random sample (n=1163) of men (aged 45 to 74 years) by determining serum IgG-antibodies to Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis.
Methods and Results--CHD (n=159) was more prevalent among edentulous than dentate subjects (19.8% and 12.1%, P=0.003). In the dentate population, CHD was more common among subjects seropositive for P. gingivalis compared with those seronegative (14.0% and 9.7%, P=0.029). Accordingly, CHD was more prevalent in subjects with a high combined antibody response than those with a low response (17.4% and 11.1%, P=0.026). When adjusted for age and several CHD risk factors, the subjects with a high combined antibody response had an odds ratio of 1.5 (95% CI, 0.95 to 2.50, P=0.077) for prevalent CHD. In a linear regression model, the combined antibody response was directly associated with prevalent CHD (P=0.046) and inversely with serum HDL cholesterol concentration (P=0.050).
Conclusions--In conclusion, edentulousness and serum antibodies to major periodontal pathogens were associated with CHD. This suggests that periodontal infection or response of the host against the infection may play a role in the pathogenesis of CHD.
Key words: atherosclerosis • cardiovascular diseases • antibodies • infection • inflammation
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