on January 9, 2003
Arteriosclerosis, Thrombosis, and Vascular Biology. 2003
Published online before print January 9, 2003, doi: 10.1161/01.ATV.0000054661.21499.FB
Published online before print January 9, 2003, doi: 10.1161/01.ATV.0000054661.21499.FB
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Submitted on September 4, 2002
Accepted on December 5, 2002
ABCA1-Deficient Mice. Insights Into the Role of Monocyte Lipid Efflux in HDL Formation and Inflammation
Robert J. Aiello *;
From Pfizer Global Research and Development, Department of Cardiovascular and Metabolic Diseases, Groton, Conn.
* To whom correspondence should be addressed. E-mail: Robert_J_Aiello{at}groton.pfizer.com.
Abstract--Studies with ATP-binding cassette transporter (ABCA1)-deficient mice have been critical in demonstrating the relation between ABCA1 expression, cellular lipid efflux, and HDL metabolism. The phenotype of the ABCA1-deficient mouse parallels the phenotype observed in human Tangier disease, including substantial reductions in both apolipoprotein B and apolipoprotein AI with confounding affects on atherosclerosis.
Key words: Tangier disease • ATP-binding cassette transporter A1 • cholesterol efflux • HDL • macrophages • atherosclerosis
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