on December 2, 2002
Arteriosclerosis, Thrombosis, and Vascular Biology. 2002
Published online before print December 2, 2002, doi: 10.1161/01.ATV.0000048856.22331.50
Published online before print December 2, 2002, doi: 10.1161/01.ATV.0000048856.22331.50
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Submitted on August 9, 2002
Accepted on November 11, 2002
Association of Hypoadiponectinemia With Coronary Artery Disease in Men
Masahiro Kumada ;
From the Department of Internal Medicine and Molecular Science (M.K., S.K., N.O., Y.A., Y.O., I.S., H.H., T.N., T.F., Y.M.), Graduate School of Medicine, Osaka University; the Department of Cardiology (S.S.), Rinku General Medical Center; the Department of Cardiology (T.K.), National Hospital Kure Medical Center; and the Department of Cardiology (S.M.), Toyonaka Municipal Hospital, Osaka, Japan.
* To whom correspondence should be addressed. E-mail: kihara{at}imed2.med.osaka-u.ac.jp.
Background—Adiponectin is an adipocyte-derived plasma protein that accumulates in the injured artery and has potential antiatherogenic properties. This study was designed to determine whether a decreased plasma adiponectin level (hypoadiponectinemia) can be independently associated with the prevalence of coronary artery disease (CAD).
Methods and Results—The consecutive 225 male patients were enrolled from inpatients who underwent coronary angiography. Voluntary blood donors (n=225) matched for age served as controls. Plasma adiponectin levels in the CAD patients were significantly lower than those in the control subjects. Multiple logistic regression analysis including plasma adiponectin level, diabetes mellitus, dyslipidemia, hypertension, smoking habits, and body mass index revealed that hypoadiponectinemia was significantly and independently correlated with CAD (P<0.0088). The entire study population was categorized in quartiles based on the distribution of plasma adiponectin levels. The interquartile cutoff points were 4.0, 5.5, and 7.0 µg/mL. The multivariate-adjusted odds ratios for CAD in the first, second, and third quartiles were 2.051 (95% confidence interval [CI], 1.288 to 4.951), 1.221 (95% CI, 0.684 to2.186), and 0.749 (95%CI, 0.392 to 1.418), respectively.
Conclusions—Male patients with hypoadiponectinemia (<4.0 µg/mL) had a significant 2-fold increase in CAD prevalence, independent of well-known CAD risk factors.
Key words: adiponectin • risk factor • coronary artery disease
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 H. H. Hegener, I-M. Lee, N. R. Cook, P. M. Ridker, and R. Y.L. Zee Association of Adiponectin Gene Variations with Risk of Incident Myocardial Infarction and Ischemic Stroke: A Nested Case-Control Study Clin. Chem., November 1, 2006; 52(11): 2021 - 2027. [Abstract] [Full Text] [PDF]
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W. Koenig, N. Khuseyinova, J. Baumert, C. Meisinger, and H. Lowel Serum Concentrations of Adiponectin and Risk of Type 2 Diabetes Mellitus and Coronary Heart Disease in Apparently Healthy Middle-Aged Men: Results From the 18-Year Follow-Up of a Large Cohort From Southern Germany J. Am. Coll. Cardiol., October 3, 2006; 48(7): 1369 - 1377. [Abstract] [Full Text] [PDF]
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H. Teoh, M. H. Strauss, P. E. Szmitko, and S. Verma Adiponectin and myocardial infarction: a paradox or a paradigm? Eur. Heart J., October 1, 2006; 27(19): 2266 - 2268. [Full Text] [PDF]
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F. Otsuka, S. Sugiyama, S. Kojima, H. Maruyoshi, T. Funahashi, K. Matsui, T. Sakamoto, M. Yoshimura, K. Kimura, S. Umemura, et al. Plasma Adiponectin Levels Are Associated With Coronary Lesion Complexity in Men With Coronary Artery Disease J. Am. Coll. Cardiol., September 19, 2006; 48(6): 1155 - 1162. [Abstract] [Full Text] [PDF]
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C. S Mantzoros, C. J Williams, J. E Manson, J. B Meigs, and F. B Hu Adherence to the Mediterranean dietary pattern is positively associated with plasma adiponectin concentrations in diabetic women. Am. J. Clinical Nutrition, August 1, 2006; 84(2): 328 - 335. [Abstract] [Full Text] [PDF]
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R. Retnakaran, A. J.G. Hanley, and B. Zinman Does Hypoadiponectinemia Explain the Increased Risk of Diabetes and Cardiovascular Disease in South Asians? Diabetes Care, August 1, 2006; 29(8): 1950 - 1954. [Full Text] [PDF]
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T. O. Kiviniemi, A. Snapir, M. Saraste, J. O. Toikka, O. T. Raitakari, M. Ahotupa, J. J. Hartiala, M. Scheinin, and J. W. Koskenvuo Determinants of coronary flow velocity reserve in healthy young men Am J Physiol Heart Circ Physiol, August 1, 2006; 291(2): H564 - H569. [Abstract] [Full Text] [PDF]
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P. E.H. Schwarz, G. W. Towers, S. Fischer, S. Govindarajalu, J. Schulze, S. R. Bornstein, M. Hanefeld, and F. Vasseur Hypoadiponectinemia Is Associated With Progression Toward Type 2 Diabetes and Genetic Variation in the ADIPOQ Gene Promoter Diabetes Care, July 1, 2006; 29(7): 1645 - 1650. [Abstract] [Full Text] [PDF]
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Y. Aso, R. Yamamoto, S. Wakabayashi, T. Uchida, K. Takayanagi, K. Takebayashi, T. Okuno, T. Inoue, K. Node, T. Tobe, et al. Comparison of Serum High-Molecular Weight (HMW) Adiponectin With Total Adiponectin Concentrations in Type 2 Diabetic Patients With Coronary Artery Disease Using a Novel Enzyme-Linked Immunosorbent Assay to Detect HMW Adiponectin. Diabetes, July 1, 2006; 55(7): 1954 - 1960. [Abstract] [Full Text] [PDF]
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 B. Iglseder, G. Ladurner, V. Mackevics, A. Stadlmayer, B. Paulweber, and G. Tasch Response to Letter by Pilz et al Stroke, July 1, 2006; 37(7): 1643 - 1643. [Full Text] [PDF]
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C. Langenberg, J. Bergstrom, C. Scheidt-Nave, J. Pfeilschifter, and E. Barrett-Connor Cardiovascular Death and the Metabolic Syndrome: Role of adiposity-signaling hormones and inflammatory markers. Diabetes Care, June 1, 2006; 29(6): 1363 - 1369. [Abstract] [Full Text] [PDF]
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N. Bansal, V. Charlton-Menys, P. Pemberton, P. McElduff, J. Oldroyd, A. Vyas, A. Koudsi, P. E. Clayton, J. K. Cruickshank, and P. N. Durrington Adiponectin in Umbilical Cord Blood Is Inversely Related to Low-Density Lipoprotein Cholesterol But Not Ethnicity J. Clin. Endocrinol. Metab., June 1, 2006; 91(6): 2244 - 2249. [Abstract] [Full Text] [PDF]
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L. J Martin, J. G Woo, S. R Geraghty, M. Altaye, B. S Davidson, W. Banach, L. M Dolan, G. M Ruiz-Palacios, and A. L Morrow Adiponectin is present in human milk and is associated with maternal factors Am. J. Clinical Nutrition, May 1, 2006; 83(5): 1106 - 1111. [Abstract] [Full Text] [PDF]
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K. Esposito, M. Ciotola, D. Carleo, B. Schisano, F. Saccomanno, F. C. Sasso, D. Cozzolino, R. Assaloni, D. Merante, A. Ceriello, et al. Effect of Rosiglitazone on Endothelial Function and Inflammatory Markers in Patients With the Metabolic Syndrome Diabetes Care, May 1, 2006; 29(5): 1071 - 1076. [Abstract] [Full Text] [PDF]
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J. Lo, S. E. Dolan, J. R. Kanter, L. C. Hemphill, J. M. Connelly, R. S. Lees, and S. K. Grinspoon Effects of Obesity, Body Composition, and Adiponectin on Carotid Intima-Media Thickness in Healthy Women J. Clin. Endocrinol. Metab., May 1, 2006; 91(5): 1677 - 1682. [Abstract] [Full Text] [PDF]
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M. von Eynatten, A. Hamann, D. Twardella, P. P. Nawroth, H. Brenner, and D. Rothenbacher Relationship of Adiponectin with Markers of Systemic Inflammation, Atherogenic Dyslipidemia, and Heart Failure in Patients with Coronary Heart Disease Clin. Chem., May 1, 2006; 52(5): 853 - 859. [Abstract] [Full Text] [PDF]
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S. E Kasim-Karakas, A. Tsodikov, U. Singh, and I. Jialal Responses of inflammatory markers to a low-fat, high-carbohydrate diet: effects of energy intake. Am. J. Clinical Nutrition, April 1, 2006; 83(4): 774 - 779. [Abstract] [Full Text] [PDF]
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I. Kowalska, M. Straczkowski, A. Nikolajuk, A. Krukowska, I. Kinalska, and M. Gorska Plasma adiponectin concentration and tumor necrosis factor-{alpha} system activity in lean non-diabetic offspring of type 2 diabetic subjects Eur. J. Endocrinol., February 1, 2006; 154(2): 319 - 324. [Abstract] [Full Text] [PDF]
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I. M. Heid, S. A. Wagner, H. Gohlke, B. Iglseder, J. C. Mueller, P. Cip, G. Ladurner, R. Reiter, A. Stadlmayr, V. Mackevics, et al. Genetic Architecture of the APM1 Gene and Its Influence on Adiponectin Plasma Levels and Parameters of the Metabolic Syndrome in 1,727 Healthy Caucasians Diabetes, February 1, 2006; 55(2): 375 - 384. [Abstract] [Full Text] [PDF]
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