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on July 18, 2002

Arteriosclerosis, Thrombosis, and Vascular Biology. 2002
Published online before print July 18, 2002, doi: 10.1161/01.ATV.0000030201.29121.A3
A more recent version of this article appeared on September 1, 2002
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Submitted on March 19, 2002
Accepted on June 28, 2002

Quantitative Trait Loci and Candidate Genes Regulating HDL Cholesterol. A Murine Chromosome Map

Xiaosong Wang and Beverly Paigen *

From The Jackson Laboratory, Bar Harbor, Me.

* To whom correspondence should be addressed. E-mail: bjp{at}jax.org.

Objective—Summarizing the many discovered mouse and human quantitative trait loci (QTL) for high density lipoprotein (HDL) cholesterol (HDL-C) levels is important for guiding future research on the genetic regulation of HDL concentrations and for finding gene targets for upregulating HDL levels in mice and humans.

Methods and Results—We summarized the 27 QTL and candidate genes associated with HDL-C concentrations in mice and plotted them on a mouse chromosome map. We also summarized the 22 human QTL for HDL-C levels and compared them with those of the mouse by comparative genomics. At least part of the mouse homologies for 18 of the 22 human HDL-C QTL were within the murine HDL-C QTL.

Conclusions—Murine QTL for HDL-C levels may predict their homologous location in humans, and their underlying genes may be appropriate genes to test in humans.
Key words: high density lipoproteins • quantitative trait loci • mouse models • cholesterol • atherosclerosis




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