on July 18, 2002
Published online before print July 18, 2002, doi: 10.1161/01.ATV.0000029972.42487.42
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Submitted on May 29, 2002
Accepted on June 21, 2002
Postprandial Enrichment of Remnant Lipoproteins With ApoC-I in Healthy Normolipidemic Men With Early Asymptomatic Atherosclerosis
Johan Björkegren *;
From the Atherosclerosis Research Unit (J.B., A.S., F.K., A.H.), King Gustaf V Research Institute, and the Cardiology Unit (S.B., U.d.F., A.H.), Department of Medicine, Karolinska Hospital, Stockholm, Sweden; the Division of Vascular Ultrasound (R.T., M.G.B.), Department of Neurobiology and Anatomy, Wake Forest University, Winston-Salem, NC; and the Division of Cardiovascular Epidemiology (U.d.F.), Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
* To whom correspondence should be addressed. E-mail: johan.bjorkegren{at}ks.se.
Objectives—Recently, we reported that exaggerated postprandial triglyceridemia in normolipidemic patients with coronary artery disease is associated with enrichment of remnant lipoproteins with apolipoprotein C-I (apoC-I). In this study, the number and composition of chylomicron remnants and very low density lipoproteins (VLDLs) were examined in 30 asymptomatic normolipidemic 50-year-old men with and without early carotid atherosclerotic lesions.
Results and Methods—Intima-media thickness of the far wall of the common carotid artery was determined by B-mode ultrasound. Triglyceride-rich lipoproteins were subfractionated by density gradient ultracentrifugation and separated into VLDL and chylomicron remnant fractions by immunoaffinity chromatography. The postprandial triglyceridemia and increase in triglyceride-rich lipoprotein particle number (ie, apolipoprotein B concentrations) were not exaggerated in men with early atherosclerosis. In contrast, their large (Svedberg flotation rate 60 to 400) and small (Svedberg flotation rate 20 to 60) chylomicron remnants and VLDL were greatly enriched with apoC-I, and their small chylomicron remnants and VLDL particles were relatively enriched with cholesterol. Moreover, the number of apoC-I molecules on small chylomicron remnants was strongly associated with the degree of atherosclerosis.
Conclusions—Early asymptomatic atherosclerosis in normolipidemic men without exaggerated postprandial triglyceridemia is associated with the enrichment of postprandial chylomicron and VLDL particles with apoC-I. Therefore, it is conceivable that the apoC-I content of lipoprotein remnants may serve as an early marker of coronary artery disease risk.
Key words: alimentary lipemia • atherosclerosis • apolipoprotein C-I • cholesterol
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