on May 9, 2002
Arteriosclerosis, Thrombosis, and Vascular Biology. 2002
Published online before print May 9, 2002, doi: 10.1161/01.ATV.0000021150.63480.CD
Published online before print May 9, 2002, doi: 10.1161/01.ATV.0000021150.63480.CD
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Submitted on January 7, 2002
Accepted on April 9, 2002
Circulating Oxidized LDL Is Associated With Subclinical Atherosclerosis Development and Inflammatory Cytokines (AIR Study)
Johannes Hulthe * and Björn Fagerberg
From The Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Göteborg University, Gothenburg, Sweden.
* To whom correspondence should be addressed. E-mail: johannes.hulthe{at}wlab.wall.gu.se.
Objective—Circulating
oxidized LDL (Ox-LDL) is associated with clinical manifestations of
atherosclerosis. However, no previous study has
examined the relationship between subclinical
atherosclerosis and Ox-LDL. The aims of the present
study were to investigate the relationship between clinically silent
ultrasound-assessed atherosclerotic changes in the carotid and femoral
arteries and Ox-LDL and to explore the relationship between Ox-LDL,
C-reactive protein, and the inflammatory cytokines
interleukin-6 and tumor necrosis
factor-
.
Methods and Results—The
study group (n=391) consisted of clinically healthy, 58-year-old men
recruited from the general population. Ox-LDL was measured by using a
specific monoclonal antibody, mAb-4E6. The results showed that Ox-LDL
was related to intima-media thickness and plaque occurrence in the
carotid and femoral arteries. In addition, Ox-LDL was associated with
tumor necrosis factor- and C-reactive protein. Circulating Ox-LDL
was also associated with LDL cholesterol but not with blood
pressure or smoking. When adjusting for other risk factors, both LDL
cholesterol and Ox-LDL seemed to be independent predictors
of plaque occurrence in the carotid and femoral arteries (odds ratios
for quintile 5 versus quintile 1 were 2.17,
P=0.049 and 2.25,
P=0.050, for LDL
cholesterol and Ox-LDL,
respectively).
Conclusions—Ox-LDL was associated with both subclinical atherosclerosis and inflammatory variables, supporting the concept that oxidatively modified LDL may play a major role in atherosclerosis development, although no causality can be shown in this cross-sectional study.
Key words: oxidized LDL • atherosclerosis • intima-media thickness • plaque • inflammation
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