on May 2, 2002
Published online before print May 2, 2002, doi: 10.1161/01.ATV.0000020676.11586.F2
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Submitted on February 4, 2002
Accepted on April 18, 2002
Curcuma longa Extract Supplementation Reduces Oxidative Stress and Attenuates Aortic Fatty Streak Development in Rabbits
José L. Quiles ;
From the Department of Physiology (J.L.Q.) and the Department of Biochemistry and Molecular Biology (M.D.M., C.M.A., Á.G., M.C.R.-T.), Granada University, and the Institute of Nutrition and Food Technology (J.L.Q., M.D.M., C.M.A., Á.G., M.C.R.-T.), University of Granada, Granada, Spain; Jaén City Hospital (C.L.R.-T.), Jaén, Spain; and the Institute of Biochemistry (M.B.), Faculty of Medicine, University of Ancona, Ancona, Italy.
* To whom correspondence should be addressed. E-mail: mramirez{at}ugr.es.
Objective—This study evaluates the effect of a Curcuma longa extract on the development of experimental atherosclerosis (fatty streak) in rabbits and its interaction with other plasmatic antioxidants.
Methods and Results—Two
experimental groups of male New Zealand White rabbits, a control
group and a curcumin-extract (CU) group, were fed an atherogenic diet.
Additionally, the CU group received an oral curcumin
hydroalcoholic extract. Six animals from each experimental group were
killed after 10, 20, and 30 days. Compared with the CU group, the
control group showed significantly higher plasma lipid peroxide at all
experimental times (10, 20, and 30 days) and significantly lower
-tocopherol and coenzyme Q levels at 20 and 30 days.
Histological results for the fatty streak lesions
revealed damage in the thoracic and abdominal aorta that was
significantly lower in the CU group than in the control group at 30
days.
Conclusions—Supplementation with Curcuma longa reduces oxidative stress and attenuates the development of fatty streaks in rabbits fed a high cholesterol diet.
Key words: Curcuma longa • antioxidants • aorta • fatty streak • atherosclerosis • rabbits
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