Transcriptional Inhibition of Protease-Activated Receptor-1 Expression by Prostacyclin in Human Vascular Smooth Muscle Cells
Arterioscler Thromb Vasc Biol Pape et al.
28: 534
Additional Materials
This data supplement includes supporting materials for this study.
Files in this Data Supplement:
- Detailed Figure Legends & Supplemental Figure 1 -
Figure 1--Inhibition of PAR-1 mRNA and total protein expression in human SMC. Figure 2--Inhibition of PAR-1 surface expression. Figure 3--Regulation of PAR-1 expression by iloprost involves Gs-/cAMP-/PKA-dependent signaling pathways. Figure 4--Downregulation of PAR-1 by iloprost depends on PKA activation. Figure 5--Downregulation of PAR-1 by iloprost attenuates the mitogenic and chemotactic response to thrombin. Supplemental Figure 1--Rac- but not Rho-dependent signaling pathways are involved in regulation of PAR-1 surface expression.
