Previous studies have shown that blocking IL18 signaling by overexpression of the IL18 binding protein (the endogenous inhibitor of IL18) prevents fatty streak formation and slows progression to mature plaque.14a
14aMallat Z, Corbaz A, Scoazec A, Graber P, Alouani S, Esposito B, Humbert Y, Chvatchko Y, Tedgui A. Interleukin18/interleukin18 binding protein signaling modulates atherosclerotic lesion development and stability. Circ Res.2001;89:e41e45.
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