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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2007;27:453.)
© 2007 American Heart Association, Inc.

ATVB In Focus

Regulation of Hemostasis and Thrombosis

Insights from Murine Models

Daniel T. Eitzman

From the Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor.

Correspondence to Daniel T. Eitzman, MD, 1150 W. Medical Center Dr., 7301 MSRB III, Ann Arbor, MI 48109-0644. E-mail deitzman@umich.edu

An extract of the first 250 words of the full text is provided, because this article has no abstract.

This issue of Arteriosclerosis, Thrombosis, and Vascular Biology contains the first of a series of articles describing the use of murine models to explore the regulation of hemostasis and thrombosis.

See page 454

Thrombotic complications of atherosclerosis, such as myocardial infarction and stroke, remain the leading cause of mortality in the Western world. Despite advances in therapies such as statins, which retard the progression of atherosclerosis and reduce vascular complications, myocardial infarction and stroke continue to dominate the healthcare system. Thus there is an urgent need to develop effective chronic therapeutic interventions for prevention of these thrombotic vascular complications. Current treatment is limited in part because of insufficient knowledge regarding the important regulatory factors in atherothrombosis and also because therapies targeting this process may also impair hemostasis leading to bleeding complications. Therapeutic interventions are similarly limited for prophylaxis of deep venous thrombosis and thrombi occurring in the atrial appendages. It is also likely that different factors affect the predisposition to thrombosis in different disease states and vascular beds, and that disease-specific antithrombotic treatments will be necessary.

Because thrombosis appears to be affected by many factors, including circulating blood cells, the vessel wall, blood flow patterns, and many other unknown elements, an in vivo model may be required to accurately assess the impact of potential important regulatory factors. Because mice are particularly amenable to genetic manipulation, the mouse has become a valuable tool to study thrombosis. There are now several models of induced and spontaneous thrombosis available in the mouse. The . . . [Full Text of this Article]

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