This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sainz, J. Articles by Sata, M. Search for Related Content PubMed PubMed Citation Articles by Sainz, J. Articles by Sata, M. Related Collections Related Articles

(Arteriosclerosis, Thrombosis, and Vascular Biology. 2007;27:263.)
© 2007 American Heart Association, Inc.

Editorials

CXCR4, a Key Modulator of Vascular Progenitor Cells

Julie Sainz; Masataka Sata

From the Departments of Cardiovascular Medicine (J.S., M.S.) and Advanced Clinical Science and Therapeutics (M.S.), University of Tokyo, Japan.

Correspondence to Dr Masataka Sata, Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. E-mail msata-circ@umin.net

An extract of the first 250 words of the full text is provided, because this article has no abstract.

A growing body of evidence suggests that circulating progenitors participate in vascular healing and remodeling under physiological and pathological conditions (Figure).^1–3 It is believed that the majority of vascular progenitor cells originate from the bone marrow. Stem cells within the bone marrow usually exist in a quiescent state. Specific signals stimulate the stem cells to differentiate and move to systemic circulation (Mobilization). Progenitors are recruited and stay at the site of vascular repair or neovascularization (Homing), where they differentiate into endothelial-like cells or smooth muscle–like cells (Differentiation) and proliferate (Proliferation). The molecular processes leading to their mobilization from the bone marrow and homing to the sites of vascular remodeling or neovascularization are not fully understood.^4,5 In the current issue of Arteriosclerosis, Thrombosis, and Vascular Biology, two articles^6,7 provide new insights into the essential role of CXCR4, the receptor for stromal cell–derived factor-1 (SDF-1) for the mobilization and the recruitment of bone marrow (BM)-derived cells. CXCR4 is notably expressed on hematopoietic stem cells and has previously been shown to play a key role in their homing and mobilization.⁸ Activation of this G protein–coupled 7-transmembrane receptor induces adhesion molecules on the hematopoietic progenitor/stem cell surface thereby enhancing their homing capacities⁹ and regulating their proliferation.¹⁰

View larger version (31K):   Contribution of bone marrow–derived cells to neointima formation and angiogenesis. On severe vascular injury, bone marrow–derived cells are recruited to the injured artery and contribute to neointima formation by differentiating into smooth muscle–like cells (left). When new vessels grow, endothelial progenitor cells (EPCs) are mobilized . . . [Full Text of this Article]

Related Articles:

M-CSF Accelerates Neointimal Formation in the Early Phase After Vascular Injury in Mice: The Critical Role of the SDF-1–CXCR4 System

Yuji Shiba, Masafumi Takahashi, Toru Yoshioka, Noriyuki Yajima, Hajime Morimoto, Atsushi Izawa, Hirohiko Ise, Kiyohiko Hatake, Kazuo Motoyoshi, and Uichi Ikeda
Arterioscler Thromb Vasc Biol 2007 27: 283-289. [Abstract] [Full Text] [PDF]

Sphingosine-1-Phosphate Stimulates the Functional Capacity of Progenitor Cells by Activation of the CXCR₄-Dependent Signaling Pathway via the S1P₃ Receptor

Dirk H. Walter, Ulrich Rochwalsky, Johannes Reinhold, Florian Seeger, Alexandra Aicher, Carmen Urbich, Ioakim Spyridopoulos, Jerold Chun, Volker Brinkmann, Petra Keul, Bodo Levkau, Andreas M. Zeiher, Stefanie Dimmeler, and Judith Haendeler
Arterioscler Thromb Vasc Biol 2007 27: 275-282. [Abstract] [Full Text] [PDF]

This article has been cited by other articles:

				K. Satoh, Y. Fukumoto, M. Nakano, K. Sugimura, J. Nawata, J. Demachi, A. Karibe, Y. Kagaya, N. Ishii, K. Sugamura, et al. Statin ameliorates hypoxia-induced pulmonary hypertension associated with down-regulated stromal cell-derived factor-1 Cardiovasc Res, January 1, 2009; 81(1): 226 - 234. [Abstract] [Full Text] [PDF]

				F. Zemani, J.-S. Silvestre, F. Fauvel-Lafeve, A. Bruel, J. Vilar, I. Bieche, I. Laurendeau, I. Galy-Fauroux, A. M. Fischer, and C. Boisson-Vidal Ex Vivo Priming of Endothelial Progenitor Cells With SDF-1 Before Transplantation Could Increase Their Proangiogenic Potential Arterioscler Thromb Vasc Biol, April 1, 2008; 28(4): 644 - 650. [Abstract] [Full Text] [PDF]

				J. Sainz and M. Sata Open Sesame!: CXCR4 Blockade Recruits Neutrophils Into the Plaque Circ. Res., February 1, 2008; 102(2): 154 - 156. [Full Text] [PDF]