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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2007;27:2275.)
© 2007 American Heart Association, Inc.

Brief Reviews

Is Metabolic Syndrome the Main Threat to Human Health in the Twenty-First Century?

Marja-Riitta Taskinen


Series Editor: Marja-Riitta Taskinen

An extract of the first 250 words of the full text is provided, because this article has no abstract.

See page 2276

Solid evidence has confirmed that the Metabolic Syndrome is associated with an increased risk of both type 2 diabetes and cardiovascular disease (CVD). Recognizing the full blown global epidemics of type 2 diabetes and obesity, the prevalence of the metabolic syndrome is rapidly growing and portends a daunting wave of CVD—a threat to human health in this century. Metabolic syndrome is a cluster of cardiometabolic risk factors that coexist in obese and insulin-resistant people. Although there has been a debate on the criteria and concept of the metabolic syndrome, the current definition by the National Cholesterol Education Program–Adult Treatment Panel (NCEP-ATP III) and the International Diabetes Federation (IDF) provide adequate screening tools to identify the subjects with high cardiometabolic risk. With these tools in hand the stage is set for attempts to discover the pathophysiology underlying these metabolic abnormalities. Over past years evidence has emerged that inflamed adipose tissue, excess visceral fat, and insulin resistance are the critical elements that contribute to the features of the metabolic syndrome. This review series aims to highlight the consequences and causes of dysfunctional adipose tissue and the ectopic accumulation of fat on atherogenesis and CVD risk factors. The identification of intracellular signaling elements and regulating factors at crossroad steps that direct the metabolic fate of lipids are critical for the understanding of atherogenic dyslipidemia in the metabolic syndrome. Importantly, several lipid metabolites seem to play a crucial role in the regulation of insulin signaling and action influencing endothelial function and . . . [Full Text of this Article]

Related Article:

Inflamed Adipose Tissue: A Culprit Underlying the Metabolic Syndrome and Atherosclerosis

Birgit Gustafson, Ann Hammarstedt, Christian X. Andersson, and Ulf Smith
Arterioscler Thromb Vasc Biol 2007 27: 2276-2283. [Abstract] [Full Text] [PDF]

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