doi: 10.1161/01.ATV.0000245798.26855.88
© 2006 American Heart Association, Inc.
Editorials |
Fibrin Gel Architecture Influences Endogenous Fibrinolysis and May Promote Coronary Artery Disease
From the Atherosclerosis Research Unit, King Gustaf V Research Institute, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden.
Correspondence to Dr Angela Silveira, PhD, King Gustaf V Research Institute, Karolinska University Hospital Solna, S-171 76 Stockholm, Sweden. E-mail Angela.Silveira@ki.se
An extract of the first 250 words of the full text is provided, because this article has no abstract. |
An altered fibrin network architecture has been associated with premature coronary artery disease (CAD).1,2 Hypofibrinolysis, ie, impaired dissolution of fibrin in blood clots, is another common finding in such patients. Hypofibrinolysis is associated with elevated activity of inhibitors of the fibrinolytic process, particularly of plasminogen activator inhibitor-1 (PAI-1)3 and thrombin activatable fibrinolysis inhibitor (TAFI),4 but it is also influenced by the characteristics of the fibrin network itself.5,6 However, previous studies on fibrin architecture, its regulation, and implications for CAD have been hampered by imperfect and/or incomplete methodology. Thus, the relationships between fibrin structure, fibrinolytic function, and premature CAD warrant further thorough examination. This issue of Arteriosclerosis, Thrombosis, and Vascular Biology features a comprehensive investigation of physical and viscoelastic characteristics of fibrin clots formed ex vivo from plasma samples, their relationships to fibrinolysis rate, and potential role in CAD.7
See page 2567
Both the morphology and mechanical properties of fibrin influence susceptibility to fibrinolysis. Fibrin structure is generally assessed by using liquid permeation, light scattering, scanning electron microscopy, and confocal microscopy, from which variables such as the fiber thickness, length and density, and the number of branch points and porosity of the network are derived.8 Blunted fibrinolysis is associated with a tight fibrin structure composed of thin and short fibers with increased number of branch points, and small pores.5,6 Individual thick fibers are actually lysed at a slower rate,9 but tight network configurations display a significantly higher fiber density compared with loose structures, which renders them more difficult to be lysed
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Arterioscler Thromb Vasc Biol 2006 26: 2567-2573.