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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2005;25:270.)
© 2005 American Heart Association, Inc.

Editorials

Are Circulating CD133⁺ Cells Biomarkers of Vascular Disease?

Gina Schatteman

From the Department of Exercise Science, University of Iowa, Iowa City.

Correspondence to Gina Schatteman, 406 Field House, Department of Exercise Science, University of Iowa, Iowa City, IA 52242-1111. E-mail gina-schatteman@uiowa.edu

An extract of the first 250 words of the full text is provided, because this article has no abstract.

Single cell bone marrow transplantation leaves no doubt as to the ability of bone marrow cells to differentiate and integrate into the endothelium, though the physiological significance of this remains controversial. Reported rates of bone marrow cell integration into the endothelium after injury vary widely, ranging from almost no cells to large percentages. Bone marrow cell maintenance of the quiescent (ie, nongrowing) vasculature has been less well studied, but at least one mouse study suggests it could be significant.¹ Whether or not large numbers of circulating cells integrate into the vessel wall, a consensus seems to be emerging that circulating bone marrow–derived cells can promote vascular growth. Exactly how this is accomplished is not clear, though it is presumably due to release of proangiogenic factors.

See page 296

Mobilization of various circulating endothelial cell progenitor (CEP)–containing populations correlates with increased vascularization in tissues undergoing neovascularization, and vascular trauma including burns, coronary artery bypass graft, and myocardial infarct all mobilize CEPs.^2–6 In light of these findings, the loss or dysfunction of CEPs could impact on vascular health. Hence, over the past several years a number of studies have begun to examine whether there is a relationship between CEP function and vascular disease. Of course, to do this, one must define a CEP. Therein lies the rub. No consensus has been reached as to what constitutes a CEP, and each laboratory seems to use a different definition. Generally speaking, CEP-containing populations that have been studied fall into two broad categories: cells related . . . [Full Text of this Article]

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