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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2003;23:365.)
© 2003 American Heart Association, Inc.

Editorials

Obesity and Oxidative Stress

A Direct Link to CVD?

Jane V. Higdon; Balz Frei

From the Linus Pauling Institute, Oregon State University, Corvallis, Ore.

Correspondence to Balz Frei, Linus Pauling Institute, 571 Weniger Hall, Oregon State University, Corvallis, OR 97331. E-mail Balz.Frei@oregonstate.edu

An extract of the first 250 words of the full text is provided, because this article has no abstract.

In this issue of Arteriosclerosis, Thrombosis, and Vascular Biology, Keaney and colleagues¹ report that smoking, diabetes, and obesity are independently associated with increased oxidative stress in men and women in a large community-based cohort. While a number of investigators have examined the association between risk factors for cardiovascular diseases (CVDs) and markers of oxidative stress in small clinical samples, Keaney and colleagues¹ used the Framingham Offspring Cohort to assess CVD risk and urinary concentrations of the F₂-isoprostane 8-epiPGF₂ in more than 2800 men and women between 33 and 88 years of age. Although smoking and diabetes have been associated with increased oxidative stress in a number of studies, the finding that obesity, as measured by body mass index (BMI), is independently associated with oxidative stress is relatively new and confirms recent data from much smaller samples.^2,3

See pages 368 and 434

F₂-Isoprostanes are prostaglandin-like products of the free radical-catalyzed peroxidation of arachidonic acid. They are formed in situ esterified to phospholipids and are released into plasma by phospholipases.⁴ Plasma and urinary F₂-isoprostanes are established biomarkers of lipid peroxidation in vivo.⁵ In humans, F₂-isoprostanes are elevated in the presence of diabetes,⁶ hypercholesterolemia,⁷ end stage renal disease and hemodialysis,⁸ hyperhomocysteinemia,⁹ and cigarette smoking.² Elevated concentrations of F₂-isoprostanes have also been found in human atherosclerotic lesions.¹⁰ In addition to serving as biomarkers of oxidative stress, F₂-isoprostanes, including 8-epiPGF₂, exert (patho)physiological effects such as vasoconstriction.¹¹

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