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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2003;23:2119.)
© 2003 American Heart Association, Inc.

Editorials

JAM-1 Regulation of Endothelial Cell Migration: Implications for Angiogenesis

Leslie V. Parise

From the Department of Pharmacology, Lineberger Comprehensive Cancer Center and Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill.

Correspondence to Leslie V. Parise, Department of Pharmacology, University of North Carolina, CB#7365, Chapel Hill, NC 27599. E-mail parise@med.unc.edu

An extract of the first 250 words of the full text is provided, because this article has no abstract.

Angiogenesis, the sprouting of new blood vessels from existing ones, is a complex process that is critical to normal growth and development, but which occurs only in very specific conditions in adults. However, abnormal angiogenic responses can arise during development (eg, hemangioma formation) and in a variety of disease states. These diseases include, but are not limited to cancers in which blood vessels develop to support tumor growth, psoriasis, pulmonary hypertension, arthritis, and vascular retinopathy that can occur in diabetes, sickle cell disease, and other disorders. Multiple therapeutic approaches with varying degrees of success have been or are being developed to limit angiogenesis. Conversely, approaches to promote angiogenesis or the related but distinct process of collateral formation are also of interest for limiting ischemic damage in conditions where insufficient blood supply contributes to the condition or limits recovery, such as in myocardial infarction, stroke and other neurodegenerative conditions, Crohn disease, and others.¹ Thus, advances in our understanding of events that occur at a molecular level to regulate blood vessel formation are of interest in providing future therapeutic targets to control these events.

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Endothelial cells (ECs) form the innermost layer of most nacsent blood vessels (there are some exceptions, such as the cytotrophoblasts that line maternal arteries in the placenta² and tumor cells that mimic ECs in some tumor blood vessels³). Angiogenesis involves an orchestration of events that include communication with and disruption of EC interaction with the surrounding extracellular matrix and neighboring cells; intracellular signaling; interplay . . . [Full Text of this Article]

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