Arteriosclerosis, Vol 8, 155-162, Copyright © 1988 by American Heart Association

ARTICLES

Coordinate changes in levels of human serum low and high density lipoprotein subclasses in healthy men

RM Krauss, PT Williams, FT Lindgren and PD Wood
Donner Laboratory, University of California, Berkeley 94720.

Measurement of serum lipoproteins by analytic ultracentrifugation revealed significant correlations involving subfractions of low density (LDL) and high density (HDL) lipoproteins in 81 men studied cross- sectionally at baseline and longitudinally during a 1-year exercise trial. One-year changes in lipoprotein levels in 38 exercising men and in 30 sedentary controls showed correlations that paralleled those observed at baseline. Positive correlations observed between plasma levels of larger, more buoyant LDL of flotation rate (Sof) 7 to 10 (LDL- I) and HDL2 may be due to processes that also coregulate changes in levels of these lipoprotein subclasses. Similarly, positive correlations among smaller, more dense LDL of Sof 2 to 6 (LDL-III), IDL, and HDL3 suggest that levels of these lipoprotein species are also coordinately regulated. An inverse correlation of change in LDL-I with change in LDL-III raises the possibility of precursor-product relationships between LDL in these categories. Thus, changes in lipoproteins which are related to coronary disease risk are not independent of one another, and the development of coronary disease may be influenced by processes linking the metabolism of individual IDL, LDL, and HDL components.

This article has been cited by other articles:

				R. M. Krauss Dietary and Genetic Probes of Atherogenic Dyslipidemia Arterioscler Thromb Vasc Biol, November 1, 2005; 25(11): 2265 - 2272. [Abstract] [Full Text] [PDF]

				R. M. Krauss Lipids and Lipoproteins in Patients With Type 2 Diabetes Diabetes Care, June 1, 2004; 27(6): 1496 - 1504. [Abstract] [Full Text] [PDF]

				K. K. Berneis and R. M. Krauss Metabolic origins and clinical significance of LDL heterogeneity J. Lipid Res., September 1, 2002; 43(9): 1363 - 1379. [Abstract] [Full Text] [PDF]

				O. A Matvienko, D. S Lewis, M. Swanson, B. Arndt, D. L Rainwater, J. Stewart, and D L. Alekel A single daily dose of soybean phytosterols in ground beef decreases serum total cholesterol and LDL cholesterol in young, mildly hypercholesterolemic men Am. J. Clinical Nutrition, July 1, 2002; 76(1): 57 - 64. [Abstract] [Full Text] [PDF]

				R. M. Krauss Atherogenic Lipoprotein Phenotype and Diet-Gene Interactions J. Nutr., February 1, 2001; 131(2): 340S - 343. [Abstract] [Full Text]

				D. M Dreon, H. A Fernstrom, P. T Williams, and R. M Krauss A very-low-fat diet is not associated with improved lipoprotein profiles in men with a predominance of large, low-density lipoproteins Am. J. Clinical Nutrition, March 1, 1999; 69(3): 411 - 418. [Abstract] [Full Text] [PDF]

				H. Campos, G. O. Roederer, S. Lussier-Cacan, J. Davignon, and R. M. Krauss Predominance of Large LDL and Reduced HDL2 Cholesterol in Normolipidemic Men With Coronary Artery Disease Arterioscler Thromb Vasc Biol, August 1, 1995; 15(8): 1043 - 1048. [Abstract] [Full Text]

				L. I. Katzel, P. J. Coon, E. Rogus, R. M. Krauss, and A. P. Goldberg Persistence of Low HDL-C Levels After Weight Reduction in Older Men With Small LDL Particles Arterioscler Thromb Vasc Biol, March 1, 1995; 15(3): 299 - 305. [Abstract] [Full Text]

				G. L. Vega and S. M. Grundy Comparison of Lovastatin and Gemfibrozil in Normolipidemic Patients With Hypoalphalipoproteinemia JAMA, December 8, 1989; 262(22): 3148 - 3153. [Abstract] [PDF]

				S. M. Grundy, D. S. Goodman, B. M. Rifkind, and J. I. Cleeman The Place of HDL in Cholesterol Management: A Perspective From the National Cholesterol Education Program Arch Intern Med, March 1, 1989; 149(3): 505 - 510. [Abstract] [PDF]