Donate Help Contact The AHA Sign In Home
American Heart Association
Arteriosclerosis, Thrombosis, and Vascular Biology
Search: search_blue_button Advanced Search
« Previous Article | Table of Contents | Next Article »
Arteriosclerosis, Thrombosis, and Vascular Biology. 1988;8:33-39

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by McGill, H. C.
Right arrow Articles by Kuehl, T. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by McGill, H. C., Jr
Right arrow Articles by Kuehl, T. J.

Arteriosclerosis, Vol 8, 33-39, Copyright © 1988 by American Heart Association

ARTICLES

Effects of selective breeding on the cholesterolemic responses to dietary saturated fat and cholesterol in baboons

HC McGill Jr, CA McMahan, GE Mott, YN Marinez and TJ Kuehl
Department of Pathology, University of Texas Health Science Center, San Antonio 78284.

Positive assortative mating of baboons (Papio sp.) based on elevation of serum cholesterol concentrations in response to a cholesterol- and saturated fat-enriched diet produced 64 progeny (30 high line; 34 low line). When the animals were 3 to 4 years of age, we tested their lipoprotein cholesterol responses to dietary cholesterol and fat in a factorial experiment with two levels of dietary cholesterol (1.7 and less than 0.01 mg/kcal) and two types of fat, coconut oil (P/S 0.1) and corn oil (P/S 3.5), each providing 40% of total calories from fat; we also tested their responses to chow. The high line animals had significantly higher very low density plus low density lipoprotein (VLDL + LDL) and high density lipoprotein (HDL) cholesterol levels on all diets. The effects of dietary cholesterol on VLDL + LDL cholesterol concentrations were greater in high line animals than in low line animals, but dietary cholesterol's effects on HDL cholesterol were similar in both lines. The effects of saturated fat, compared to unsaturated fat, on both VLDL + LDL and HDL cholesterol levels were similar in both lines. Selective breeding produced lines diverging in lipoprotein cholesterol concentrations by acting on several different genetically mediated processes that control serum lipoprotein levels. At least one of these processes involves responsiveness of serum VLDL + LDL cholesterol concentration to dietary cholesterol.


This article has been cited by other articles:


Home page
 Am. J. Clin. Nutr.Home page
D. L Rainwater, M. C Mahaney, J. L VandeBerg, and X. L. Wang
Vitamin E dietary supplementation significantly affects multiple risk factors for cardiovascular disease in baboons
Am. J. Clinical Nutrition, September 1, 2007; 86(3): 597 - 603.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
L. A. Cox, S. Birnbaum, and J. L. VandeBerg
Identification of Candidate Genes Regulating HDL Cholesterol Using a Chromosomal Region Expression Array
Genome Res., November 1, 2002; 12(11): 1693 - 1702.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. L. Rudel, M. Davis, J. Sawyer, R. Shah, and J. Wallace
Primates Highly Responsive to Dietary Cholesterol Up-regulate Hepatic ACAT2, and Less Responsive Primates Do Not
J. Biol. Chem., August 23, 2002; 277(35): 31401 - 31406.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
D. L. Rainwater, C. M. Kammerer, J. E. Hixson, K. D. Carey, K. S. Rice, B. Dyke, J. F. VandeBerg, S. H. Slifer, L. D. Atwood, H. C. McGill Jr, et al.
Two Major Loci Control Variation in ß-Lipoprotein Cholesterol and Response to Dietary Fat and Cholesterol in Baboons
Arterioscler Thromb Vasc Biol, July 1, 1998; 18(7): 1061 - 1068.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
R. S. Kushwaha, B. Guntupalli, K. S. Rice, K. D. Carey, and H. C. McGill Jr
Effect of Dietary Cholesterol and Fat on the Expression of Hepatic Sterol 27-Hydroxylase and Other Hepatic Cholesterol-Responsive Genes in Baboons (Papio Species)
Arterioscler Thromb Vasc Biol, September 1, 1995; 15(9): 1404 - 1411.
[Abstract] [Full Text]


ATVB Home | Subscriptions | Archives | Feedback | Authors | Help | AHA Journals Home | Search
Copyright © 1988 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited.