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Arteriosclerosis, Thrombosis, and Vascular Biology. 1987;7:267-275

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Arteriosclerosis, Vol 7, 267-275, Copyright © 1987 by American Heart Association

ARTICLES

Synthesis and secretion of plasma cholesteryl ester transfer protein by human hepatocarcinoma cell line, HepG2

RA Faust and JJ Albers

We have examined the synthesis, secretion, and functional and physical characteristics of a lipid transfer protein synthesized by a human hepatocellular carcinoma line. We found that this protein shares immunochemical determinants and many other properties with the lipid transfer protein, LTP-I, which has been purified from human plasma. We conclude that the human liver cell line, HepG2, synthesizes and secretes LTP-I. Thus, hepatocytes may be the source of LTP-I in human plasma.


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