Arteriosclerosis, Vol 6, 131-138, Copyright © 1986 by American Heart Association

ARTICLES

Regional accumulations of T cells, macrophages, and smooth muscle cells in the human atherosclerotic plaque

L Jonasson, J Holm, O Skalli, G Bondjers and GK Hansson

The cellular composition of human atherosclerotic plaques was analyzed by immunologic techniques. Plaques were removed from the internal carotid artery during surgery, and a panel of monoclonal antibodies was used to identify cell types. Macrophages stained by Anti-Leu-M3 were found throughout the plaque, particularly in the lipid core region, where 60% of the cells reacted with this antibody. T cells expressing the T3 antigen were most abundant in the fibrous cap, where they constituted 20% of the cell population. T cells were also isolated from the plaque and detected by a rosetting test; many of these T cells were activated, as indicated by the expression of HLA-DR. Other types of leukocytes were uncommon in the plaque. An antibody to the intermediate filament protein, desmin, was used as a marker for smooth muscle cells since some, but not all, vascular smooth muscle cells contain this protein. The desmin-positive cells were uncommon in the nonatherosclerotic intima but were more numerous in the plaque. In conclusion, atherosclerotic plaques are heterogeneous with respect to cellular composition. The smooth muscle cell dominates in the fibrous cap, which also contains many T cells; the lipid core is dominated by macrophages. We suggest that interactions between smooth muscle cells and blood-borne cells are important in the pathogenesis of atherosclerosis.

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				M. E. Ritchie Nuclear Factor-{kappa}B Is Selectively and Markedly Activated in Humans With Unstable Angina Pectoris Circulation, October 27, 1998; 98(17): 1707 - 1713. [Abstract] [Full Text] [PDF]

				E. Nishi, N. Kume, Y. Ueno, H. Ochi, H. Moriwaki, and T. Kita Lysophosphatidylcholine Enhances Cytokine-Induced Interferon Gamma Expression in Human T Lymphocytes Circ. Res., September 7, 1998; 83(5): 508 - 515. [Abstract] [Full Text] [PDF]

				S. Jander, M. Sitzer, R. Schumann, M. Schroeter, M. Siebler, H. Steinmetz, and G. Stoll Inflammation in High-Grade Carotid Stenosis : A Possible Role for Macrophages and T Cells in Plaque Destabilization Stroke, August 1, 1998; 29(8): 1625 - 1630. [Abstract] [Full Text] [PDF]

				M. Okada, A. Matsumori, K. Ono, Y. Furukawa, T. Shioi, A. Iwasaki, K. Matsushima, and S. Sasayama Cyclic Stretch Upregulates Production of Interleukin-8 and Monocyte Chemotactic and Activating Factor/Monocyte Chemoattractant Protein-1 in Human Endothelial Cells Arterioscler Thromb Vasc Biol, June 1, 1998; 18(6): 894 - 901. [Abstract] [Full Text] [PDF]

				P. Schratzberger, S. Dunzendorfer, N. Reinisch, C. M Kahler, M. Herold, and C. J Wiedermann Release of chemoattractants for human monocytes from endothelial cells by interaction with neutrophils Cardiovasc Res, May 1, 1998; 38(2): 516 - 521. [Abstract] [Full Text] [PDF]

				H.-Y. Hsu, D. P. Hajjar, K. M. F. Khan, and D. J. Falcone Ligand Binding to Macrophage Scavenger Receptor-A Induces Urokinase-type Plasminogen Activator Expression by a Protein Kinase-dependent Signaling Pathway J. Biol. Chem., January 9, 1998; 273(2): 1240 - 1246. [Abstract] [Full Text] [PDF]

				H. Funayama, U. Ikeda, M. Takahashi, Y. Sakata, S.-I. Kitagawa, Y.-I. Takahashi, J.-I. Masuyama, Y. Furukawa, Y. Miura, S. Kano, et al. Human monocyte-endothelial cell interaction induces platelet-derived growth factor expression Cardiovasc Res, January 1, 1998; 37(1): 216 - 224. [Abstract] [Full Text] [PDF]

				H. O. Andersen, P. Holm, S. Stender, B. F. Hansen, and B. G. Nordestgaard Dose-Dependent Suppression of Transplant Arteriosclerosis in Aorta-Allografted, Cholesterol-Clamped Rabbits : Suppression Not Eliminated by the Cholesterol-Raising Effect of Cyclosporine Arterioscler Thromb Vasc Biol, November 1, 1997; 17(11): 2515 - 2523. [Abstract] [Full Text]

				J. R Oksenberg, G. T Stavri, M. C Jeong, Natara Garovoy, J. R Salisbury, and J. D Erusalimsky Analysis of the T-cell receptor repertoire in human atherosclerosis Cardiovasc Res, November 1, 1997; 36(2): 256 - 267. [Abstract] [Full Text] [PDF]

				V. A. Folcik, R. Aamir, and M. K. Cathcart Cytokine Modulation of LDL Oxidation by Activated Human Monocytes Arterioscler Thromb Vasc Biol, October 1, 1997; 17(10): 1954 - 1961. [Abstract] [Full Text]