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Arteriosclerosis, Thrombosis, and Vascular Biology. 1984;4:265-269

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Arteriosclerosis, Vol 4, 265-269, Copyright © 1984 by American Heart Association

ARTICLES

Effect of a diet low in saturated fatty acids on plasma lipids, lipoproteins, and HDL subfractions

C Ehnholm, JK Huttunen, P Pietinen, U Leino, M Mutanen, E Kostiainen, JM Iacono, R Dougherty and P Puska

The effect on serum high density lipoprotein subfractions of a low fat diet with a high ratio of polyunsaturated-to-saturated fatty acids was studied in 38 middle-aged volunteers (19 men and 19 women) in North Karelia, Finland. The mean serum HDL2 cholesterol decreased from 32 +/- 2 mg/dl (mean +/- SE) to 28 +/- 2 mg/dl (p less than 0.001) during the experimental diet and returned to 33 +/- 2 mg/dl (p less than 0.001) after a return to the original diet. No changes were observed in the concentration of HDL3 cholesterol. A highly significant decrease was observed in serum apoprotein A-I concentration, but not in apoprotein A- II concentration during the experimental diet. It is concluded that a low-fat, high-P/S ratio diet lowers LDL and HDL2 cholesterol in healthy volunteers, but does not influence the level of HDL3 subfraction.


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